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Age- and cytokine-dependent modulation of GABAergic transmission within the basolateral amygdala of male Sprague Dawley rats.
Neuropharmacology
January 2025
Developmental Exposure Alcohol Research Center, Behavioral Neuroscience Program, Department of Psychology, Binghamton, NY, 13902-6000, USA. Electronic address:
Alcohol binge drinking has a multitude of effects on CNS function, including changes in inflammatory cytokines such as IL-6 and IL-1β that may contribute to mood fluctuations associated with the intoxication-withdrawal cycle. Widely throughout the brain, including the amygdala, IL-6 mRNA is enhanced during intoxication, whereas IL-1β is initially suppressed during alcohol intoxication, with increased expression seen shortly after ethanol clearance, during acute hangover. Furthermore, induction of neuroimmune genes appears to be muted during adolescence in the amygdala, suggesting a broader functional immaturity of the adolescent neuroimmune system in structures involved in negative affect associated with ethanol exposure.
View Article and Find Full Text PDFType 2 Cytokine-Dependent Skin Barrier Regulation in Personalized 2-Dimensional and 3-Dimensional Skin Models of Atopic Dermatitis: A Pilot Study.
JID Innov
January 2025
Department of Dermatology, University Hospital Schleswig-Holstein, Kiel, Germany.
Article Synopsis
- Researchers are exploring keratinocytes (KCs) from patients with atopic dermatitis (AD) to study inflammatory responses, suggesting they may better represent AD conditions than KCs from healthy individuals.
- * The study found that KCs from AD patients showed greater expression of AD-related markers when stimulated with cytokines IL-4 and IL-13 compared to those from healthy donors.
- * Hair follicle-derived KCs from AD patients provide a promising noninvasive model for understanding AD-related inflammation and can mimic the disease's features in laboratory setups.
High sugar diet-induced fatty acid oxidation potentiates cytokine-dependent cardiac ECM remodeling.
J Cell Biol
September 2024
Department of Biological Sciences, Molecular Cell and Developmental Biology Laboratory, Indian Institute of Science Education and Research Mohali, Punjab, India.
Article Synopsis
- - High-caloric diets can disrupt the extracellular matrix (ECM) in organs, particularly the heart, leading to health issues, though the exact mechanisms are not well understood.
- - Research using Drosophila shows that high sugar intake activates JNK signaling, resulting in increased fatty acid oxidation (FAO) in specific cells, which then upregulates the cytokine Unpaired 3 (Upd3).
- - The release of Upd3 prompts the expression of the ECM protein Pericardin, causing cardiac fibrosis, highlighting a novel connection between FAO and ECM remodeling that could have implications for diabetic complications.
Cirrhosis-downregulated LSECtin can be retrieved by cytokines, shifts the TLR-induced LSECs secretome and correlates with the hepatic Th response.
Liver Int
April 2024
Hepatic and Intestinal Immunobiology Group, Departamento de Medicina Clínica, Universidad Miguel Hernández, San Juan de Alicante, Spain.
Background And Aims: We evaluated tolerogenic C-type lectin LSECtin loss in cirrhosis and its potential regulation by cytokines.
Methods: Liver tissue from patients with cirrhosis and healthy controls, immortalised and generated LSECtin-CRISPR immortalised LSECs, and murine primary LSECs from the CCl model were handled.
Results: LSECtin expression was reduced in liver tissue from cirrhotic patients, and it decreased from compensated to decompensated disease.
Regulation of the JAK/STAT signaling pathway in spinal cord injury: an updated review.
Front Immunol
December 2023
Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Cytokines are involved in neural homeostasis and pathological processes associated with neuroinflammation after spinal cord injury (SCI). The biological effect of cytokines, including those associated with acute or chronic SCI pathologies, are the result of receptor-mediated signaling through the Janus kinases (JAKs) as well as the signal transducers and activators of transcription (STAT) DNA-binding protein families. Although therapies targeting at cytokines have led to significant changes in the treatment of SCI, they present difficulties in various aspects for the direct use by patients themselves.
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