AI Article Synopsis
- The study aimed to investigate the renoprotective effects of Rehmannia glutinosa, a traditional herbal remedy, in cases of progressive renal failure.
- The research involved analyzing various factors related to kidney function and specific protein expressions in rats with induced renal failure, using a 5/6 nephrectomy model.
- Results indicated that Rehmannia glutinosa could lower serum creatinine levels, decrease proteinuria, and inhibit harmful protein expressions associated with kidney damage, suggesting its potential protective mechanisms.
Article Abstract
Aim Of The Study: Rehmannia glutinosa, the steamed root of the Scrophulariaceae family, has been widely used in Asian countries for the treatment of renal diseases. In this study, we evaluated the renoprotective effect of aqueous extract of Rehmannia glutinosa in progressive renal failure.
Materials And Methods: The effects of Rehmannia glutinosa on renal function, 24-h proteinuria, and the expression of angiotensin II, angiotensin II type 1 (AT(1)) receptor, TGF-beta1, and type IV collagen in renal cortex were analyzed in progressive renal failure rats induced by 5/6 nephrectomy.
Results: Rehmannia glutinosa reduced the serum creatinine level, 24-h urinary protein excretion, and glomerulosclerosis, and it also inhibited the expression of angiotensin II, AT(1) receptor, TGF-beta1 and type IV collagen in the renal cortex.
Conclusions: These results suggest that the renoprotective effect of Rehmannia glutinosa might be mediated by suppressing the expression of angiotensin II and AT(1) receptor and by regulating TGF-beta1 and type IV collagen expression.
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| http://dx.doi.org/10.1016/j.jep.2008.12.015 | DOI Listing |
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