Aim: To evaluate the effects of orthodontic treatment among individuals with Class II Division 1 malocclusion and severe overbite.
Methods: The sample was made up of 70 patients (35 males and 35 females), with an average age of 11.6 years in pretreatment and 14.9 years in posttreatment. One hundred forty lateral cephalograms were obtained and traced by a single investigator. All individuals were treated with the edgewise technique associated with the Kloehn cervical extraoral headgear during the growth spurt, and simultaneously presented ANB > or = 5 degrees and overbite > or = 4 mm. Statistical analysis involved t tests for both independent and paired samples and the Spearman correlation test.
Results: There were no significant differences between genders regarding the effects of treatment. The cases treated with extraction presented a greater reduction in the SNA angle. On average, all the variables of the study were significantly different when comparing the pretreatment and posttreatment conditions, except for the measurement of the mandibular plane angle (SNGoMe).
Conclusion: Correction of severe overbite occurred in virtue of the intrusion of the maxillary and mandibular incisors associated to a reduction of the maxillary prognathism and differential growth of the mandible, as well as dentoalveolar growth.
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J Clin Immunol
December 2024
Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Bologna, Italy.
Background: Activated Phosphoinositide 3-Kinase (PI3K) δ Syndrome (APDS), an inborn error of immunity due to upregulation of the PI3K pathway, leads to recurrent infections and immune dysregulation (lymphoproliferation and autoimmunity).
Methods: Clinical and genetic data of 28 APDS patients from 25 unrelated families were collected from fifteen Italian centers.
Results: Patients were genetically confirmed with APDS-1 (n = 20) or APDS-2 (n = 8), with pathogenic mutations in the PIK3CD or PIK3R1 genes.
J Microbiol Biol Educ
December 2024
Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Many educational institutions transitioned to digital distance-based learning and assessment formats in 2020 due to the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) pandemic. This shift has often been associated with concerns about increased student cheating and heightened stress. In this study, we compared the major course assessment grades of students in a microbiology course delivered through a digital distance-based format, including a take-home examination and a examination during 2020, 2021, and 2022 ( = 127) with those who took the course in a traditional, live, in-person format with an in-class examination in 2019 ( = 45).
View Article and Find Full Text PDFHead Neck
December 2024
Department of Surgical Oncology, Division of Head and Neck Surgery, National Cancer Institute, Cairo University, Cairo, Egypt.
Background: The submental artery island flap (SIF) is a valid option for palatal reconstruction. However, the main limitation for its application for palatal defects is the arc of rotation. A novel modification for tunneling of the antegrade design of SIF that allows a compliant easy reach to the defect is described.
View Article and Find Full Text PDFNeuro Oncol
December 2024
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institut für Neuropathologie, Charitéplatz 1, 10117 Berlin, Germany.
Background: Intracerebral schwannomas are rare tumors resembling their peripheral nerve sheath counterparts but localized in the CNS. They are not classified as a separate tumor type in the 2021 WHO classification. This study aimed to compile and characterize these rare neoplasms morphologically and molecularly.
View Article and Find Full Text PDFAdv Mater
December 2024
Department of Materials Science and Engineering, University of California, Berkeley, CA, 94720, USA.
Rationalizing synthetic pathways is crucial for material design and property optimization, especially for polymorphic and metastable phases. Over-stoichiometric rocksalt (ORX) compounds, characterized by their face-sharing configurations, are a promising group of materials with unique properties; however, their development is significantly hindered by challenges in synthesizability. Here, taking the recently identified Li superionic conductor, over-stoichiometric rocksalt Li-In-Sn-O (o-LISO) material as a prototypical ORX compound, the mechanisms of phase formation are systematically investigated.
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