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Inter-Island Variability in Trace Elements and Trophic Ecology of Brown Booby (Sula leucogaster) in the South Atlantic.
Environ Pollut
January 2025
Olaf Malm Laboratory of Environmental Studies (LEA-OM), Carlos Chagas Filho Biophysics Institute (IBCCF), Federal University of Rio de Janeiro (UFRJ), 21941-902, Rio de Janeiro, Brazil; Laboratory of Oceanology, Freshwater and Oceanic Sciences Unit of Research (FOCUS), University of Liege, Belgium.
This study investigates essential (Mg, Ca, Fe, Mn, Cu, Zn, Se, Ni) and non-essential (Li, Be, Cr, Rb, Sr, Cs, Cd, Sn, Ba, and Pb) element concentrations and stable isotope (δC, δN, δS) compositions in feathers of Brown Boobies (Sula leucogaster) from three distinct Atlantic islands: the Archipelagos of Saint Peter and Saint Paul (SPSP), Abrolhos, and Cagarras. We aimed to investigate the ecological and environmental factors influencing these seabird populations and assess potential variations in contaminant exposure and dietary habits based on location, sex, and maturity stages. Our finding revealed significant geographical differences in trace element concentrations.
View Article and Find Full Text PDFBackground: Subtle changes in naturalistic language have been associated with cognitive abilities in older adults. This study explored script generation as a method for detection of mild cognitive impairment (MCI). Differences in human-coded speech analysis of scripts were examined between MCI vs.
View Article and Find Full Text PDFEvidence linking cadmium and/or lead exposure to immunomodulatory effects in mammals based upon an adverse outcome pathways approach, and research perspectives.
Chemosphere
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Laboratoire Chrono-Environnement, UMR 6249, CNRS/Université de Franche-Comté, 16 route de Gray, 25000, Besançon, France.
For decades, studies have shown how exposure to non-essential trace metals such as lead (Pb) and cadmium (Cd) largely impact global wildlife. Ecoimmunotoxicology has emerged in the past two decades and focuses on the effects of pollutants on the immune system of free-ranging organisms. Adverse outcome pathways (AOPs) represent a conceptual approach to explore the mechanistic linkage between a molecular initiating event and adverse outcomes, potentially at all biological levels of organisation.
View Article and Find Full Text PDFTransposon-sequencing across multiple isolates reveals significant functional genomic diversity among strains.
mBio
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Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Unlabelled: ) is a clinically significant pathogen and a highly genetically diverse species due to its large accessory genome. The functional consequence of this diversity remains unknown mainly because, to date, functional genomic studies in have been primarily performed on reference strains. Given the growing public health threat of infections, understanding the functional genomic differences among clinical isolates can provide more insight into how its genetic diversity influences gene essentiality, clinically relevant phenotypes, and importantly, potential drug targets.
View Article and Find Full Text PDFGenetic modulation of RNA splicing rescues BRCA2 function in mutant cells.
Life Sci Alliance
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Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal
Variants in the hereditary cancer-associated and genes can alter RNA splicing, producing transcripts that encode internally truncated yet potentially functional proteins. However, few studies have quantitatively analyzed variant-specific splicing isoforms. Here, we investigated cells heterozygous and homozygous for the :c.
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