AI Article Synopsis
- The MYO9B gene's SNPs have been linked to inflammatory and autoimmune diseases in recent studies.
- Researchers examined the relationship between MYO9B variants and multiple sclerosis (MS) in four Northern European populations.
- Despite testing 18 SNPs among MS families and analyzing variants in large control groups, no significant associations were found, indicating that these MYO9B variants likely do not play a major role in MS.
Article Abstract
Single-nucleotide polymorphisms (SNPs) in the 3' region of myosin IXB (MYO9B) gene have recently been reported to associate with different inflammatory or autoimmune diseases. We monitored for the association of MYO9B variants to multiple sclerosis (MS) in four Northern European populations. First, 18 SNPs including 6 SNPs with previous evidence for association to immune disorders, were tested in 730 Finnish MS families, but no linkage or family-based association was observed. To ensure the power to detect variants with a modest effect size, we further analyzed 10 variants in 899 Finnish cases and 1325 controls, and in a total of 1521 cases and 1476 controls from Denmark, Norway and Sweden, but found no association. Our results thereby do not support a major function of the tested MYO9B variants in MS.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685895 | PMC |
| http://dx.doi.org/10.1038/ejhg.2008.251 | DOI Listing |
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