We have studied the effects of chronic peripheral infusion of Neuropeptide Y (NPY) and norepinephrine (NE) alone and together. Do these hormones additively affect the metabolic activity of Brown adipost tissue (BAT in obese animals? 20 obese (fa/fa) Zucker strain rats were studied. The diameter of the triglyceride droplets (TGDs) was measured as an indicator of the BAT metabolic activity. We confirmed that in these animals NE alone did not stimulated BAT metabolic activity. Neither did NPY alone. NPY and NE together caused significant induction of BAT metabolic activity as indicated by severe reduction in the TGD diameter.
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