AI Article Synopsis
- Epithelioid sarcoma (ES) is a rare cancer with a generally poor prognosis, often characterized by the loss of INI1 expression.
- In a study of 106 ES cases, INI1 was found to be negative in 86 cases, with similar percentages in both conventional (81%) and large cell (81%) subtypes.
- While INI1 loss can serve as a diagnostic marker, factors like tumor size and mitotic index significantly affected patient outcomes, but INI1 loss itself did not impact prognosis.
Article Abstract
Epithelioid sarcoma (ES) is rare with a poor prognosis and for which a loss of INI1 expression has been recently reported. We report a study of 106 cases with clinical, histologic, and immunohistochemical data, including INI1 expression, and follow-up data. Of the 106 cases, 70 were the conventional subtype and 36 the large cell subtype. INI1 was negative in 86 cases (81.1%): 57 (81%) of 70 conventional and 29 (81%) of 36 large cell subtypes. Treatment modalities were available for 76 and follow-up for 80 patients. Of the 80 patients, 43 (54%) experienced metastasis and 25 (31%) died of the disease. Univariate analysis indicated that tumor size and mitotic index were significant for metastasis-free survival, whereas proximal location, tumor size, tumor multifocality, and mitotic index were significant for overall survival. Loss of expression of INI1 is frequent in the conventional and large cell subtypes of ES and can be used as a diagnostic marker, but it has no prognostic impact.
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| http://dx.doi.org/10.1309/AJCPU98ABIPVJAIV | DOI Listing |
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