Expression of four housekeeping proteins in elderly patients with schizophrenia.

J Neural Transm (Vienna)

Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, SC560, 1530 3rd Ave S., Birmingham, AL, 35294-0017, USA.

Published: April 2009

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Article Abstract

We compared protein expression by Western blot analysis in four areas of postmortem brain from patients with schizophrenia and control subjects for several proteins that are often used as controls for Western blot studies: beta-tubulin, actin, glyceraldehyde-3-phosphate dehydrogenase, and valosin-containing protein. We did not detect any differences in expression between subjects with schizophrenia and a comparison group. These results suggest that all four proteins are suitable loading controls for postmortem studies of schizophrenia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734379PMC
http://dx.doi.org/10.1007/s00702-008-0143-3DOI Listing

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