We report a case of primary non-Hodgkin's lymphoma of the humerus that occurred in a 21-year-old male patient. A previously healthy man presented with the history of severe pain and a differential diagnosis from osteomyelitis to malignant lesion was suspected. A biopsy was performed and the final pathologic diagnosis was a diffuse large B-cell lymphoma. The patient was treated for lymphoma only with radiotherapy. To date, the patient remains tumor free 10 years after the onset of the disease.

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