The slow process required for alpha-synuclein to form amyloid fibrils is a major obstacle in the development of therapeutic compounds for alpha-synuclein-related neurodegenerative diseases such as Parkinson's disease (PD). Here we have developed an efficient method by which amyloid fibrils can be formed from alpha-synuclein using ionic liquids (ILs). This report indicates that ILs could potentially be used as a stimulator for the amyloid formation of alpha-synuclein.
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| http://dx.doi.org/10.1016/j.ab.2008.12.019 | DOI Listing |
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