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Ergotamine-induced vasospastic ischemia mimicking arterial embolism: unusual case.
Ulus Travma Acil Cerrahi Derg
July 2014
Department of Radiology, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Turkey.
Ergotamine toxicity is an important and rare condition, including tachycardia, arterial spasm which occurring as a result of accidental overdosing or drug interactions. We assessed the consequences of delayed diagnosis of peripheral arterial vasoconstriction occurring after simultaneous macrolide use by a 35-year-old woman using an ergot-derived drug for migraine. Diagnosis of ergotamine intoxication begins with suspicion.
View Article and Find Full Text PDFFrom headache to heartache: ergotamine-induced aortic and mitral valvulopathy.
J Am Coll Cardiol
December 2013
Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Pharmacological identification of α1- and α2-adrenoceptor subtypes involved in the vasopressor responses induced by ergotamine in pithed rats.
Eur J Pharmacol
September 2013
Departamento de Farmacobiología, Cinvestav-Coapa, Czda. de los Tenorios 235, Col. Granjas-Coapa, Deleg. Tlalpan, C.P. 14330 México D.F., México.
Ergotamine has been used in clinical practice for the acute treatment of migraine for over 90 years. So far, it is known that ergotamine interacts with diverse receptors (including α1/2-adrenoceptors, 5-HT1, 5-HT2 and D2-like receptors) and that produces increases in mean blood pressure which are significantly blocked by yohimbine, a classical α2-adrenoceptor antagonist with a moderate affinity for α1-adrenoceptors. Since α1/2-adrenoceptors mediate vasopressor and vasoconstrictor responses in the cardiovascular system, this study was designed to identify the α-adrenoceptor subtypes (α1A, α1B, α1D, α2A, α2B and α2C) involved in ergotamine-induced vasopressor responses in pithed rats.
View Article and Find Full Text PDFCardiac surgery for ergotamine-induced multivalvular heart disease.
Thorac Cardiovasc Surg
August 2013
Department of Cardiac Surgery, Athens Medical Center, Athens, Greece.
Ergotamine is used to abort or prevent vascular headache. Valvular heart disease as an adverse effect of long-term ergotamine therapy has been rarely reported in the English literature, with only a few cases published. It is hypothesized that ergot-derived agents stimulate serotonergic receptors (5-HT2B), causing proliferation of myofibroblasts, with subsequent thickening of valve leaflets and chords.
View Article and Find Full Text PDFErgotamine-induced lower extremity arterial vasospasm presenting as acute limb ischemia.
Diagn Interv Radiol
June 2010
Department of Radiology, Başkent University Adana Medical and Research Center, Adana, Turkey.
Ergotamine-induced limb ischemia is rare and usually results from an accidental overdose. Several agents, including erythromycin and tetracycline, raise serum ergotamine levels and augment its effect. We present a case of acute lower limb ischemia with characteristic angiography findings of diffuse arterial spasm resulting from use of ergotamine and an erythromycin derivative, clarithromycin.
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