AmpC overexpression (AmpC++) is a significant mechanism of beta-lactam resistance in Pseudomonas aeruginosa, but its impact on clinical outcomes is not well established. To examine the influence of AmpC++ on clinical outcomes of patients with P. aeruginosa bacteremia, we screened all bloodstream P. aeruginosa isolates obtained from 2003 to 2006 for AmpC++. Demographics and outcomes were retrospectively compared between patients with P. aeruginosa bacteremia caused by AmpC++ and pan-susceptible strains (wild-type controls). Of the 263 isolates screened, 63 (24.0%) were nonsusceptible to ceftazidime. Clinical data of 42 AmpC++ isolates from 21 patients were compared with 33 control patients. The 2 groups were similar in sex and race. Patients in the AmpC++ group was more likely to receive inappropriate empiric antibiotics (odds ratio [OR] = 67.5; 95% confidence interval [CI], 6.3-720.0) and experience microbiologic persistence (OR = 12.2; 95% CI, 1.7-87.7). In institutions with a high prevalence of AmpC++, empiric therapy with agents with activity against AmpC++ strains may be warranted.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.diagmicrobio.2008.11.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparative analysis of virulence factors produced by strains isolated from chronic wounds or bloodstream infections.
MicroPubl Biol
December 2024
Departamento de Tecnologia Farmacêutica, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.
is an important pathogen associated with both chronic wounds and bloodstream infections. Virulence factors required for the establishment of acute and chronic infections differ substantially. Since bacteremia can be a severe outcome of wound colonization, we performed a comparative analysis of virulence between strains isolated from the bloodstream and chronic wounds.
View Article and Find Full Text PDF[Healthcare-Associated Infections in Pediatric Patients: A Decade of Experience in an Intensive Care Unit].
Acta Med Port
January 2025
Introduction: Healthcare-associated infections are an important cause of morbidity and mortality in the pediatric population and a growing problem in intensive care services. However, limited data are available on these infections in the Portuguese pediatric population. This study aimed to estimate its prevalence rate in a Portuguese pediatric intensive care unit, identifying the most frequent microorganisms and their antibiotic resistance profiles.
View Article and Find Full Text PDFGlobal and Regional Burden of Bloodstream Infections Caused by Carbapenem-Resistant Gram-Negative Bacteria in 2019: A Systematic Analysis from the MICROBE Database.
Int J Infect Dis
December 2024
Department of Respiratory Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, 241000, China. Electronic address:
Objectives: To quantify the global and regional burden of bloodstream infections associated with and attributable to carbapenem-resistant Gram-negative bacteria.
Methods: We extracted data from the MICROBE database, which includes the estimated burden of 23 pathogens and 88 pathogen-drug combinations across 12 major infectious syndromes globally in 2019. The number and rate of deaths, as well as disability-adjusted life-years linked to bloodstream infections, were systematically analyzed.
Mutations in mexT bypass the stringent response dependency of virulence in Pseudomonas aeruginosa.
Cell Rep
December 2024
Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK. Electronic address:
Pseudomonas aeruginosa produces a wealth of virulence factors whose production is controlled via an intricate regulatory systems network. Here, we uncover a major player in the evolution and regulation of virulence that enhances host colonization and antibiotic resistance. By characterizing a collection of mutants lacking the stringent response (SR), a system key for virulence, we show that the loss of the central regulator MexT bypasses absence of the SR, restoring full activation of virulence pathways.
View Article and Find Full Text PDFBackground: Ceftolozane-tazobactam and ceftazidime-avibactam are preferred treatment options for multidrug-resistant Pseudomonas aeruginosa infections; however, real-world comparative effectiveness studies are scarce. Pharmacokinetic and pharmacodynamic differences between the agents might affect clinical response rates. We aimed to compare the effectiveness of ceftolozane-tazobactam and ceftazidime-avibactam for treatment of invasive multidrug-resistant P aeruginosa infections.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!