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Protective effects of Lactobacillus plantarum strain against protein malnutrition-induced muscle atrophy and bone loss in juvenile mice.
PLoS One
January 2025
School of Biological Sciences, Seoul National University, Seoul, South Korea.
Early-life malnutrition adversely affects nearly all organ systems, resulting in multiple physiological adaptations, including growth restriction and muscle and bone loss. Although there is growing evidence that probiotics effectively improve systemic growth under malnourished conditions in different animal models, our knowledge of the beneficial effects of probiotics on various organs is limited. Here, we show that Lactobacillus plantarum strain WJL (LpWJL) can mitigate skeletal muscle and bone loss in protein-malnourished juvenile mice.
View Article and Find Full Text PDFMultifactorial effects of probiotic Parasutterella excrementihominis on gestational inflammation, offspring behaviour and prenatal-stress induced disruptions in tryptophan metabolism.
Benef Microbes
November 2024
Department of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Article Synopsis
- Prenatal stress (PNS) negatively impacts offspring by disrupting immune development and causing behavioral issues, with the gut microbiome playing a crucial role in this process.
- The study tested the hypothesis that PNS leads to an imbalance in tryptophan (Trp) metabolism and that the bacteria Parasutterella excrementihominis could mitigate these effects in stressed pregnant mice.
- Results showed that P. excrementihominis treatment reduced excessive maternal gut Trp levels and inflammation, which in turn improved the inflammatory and behavioral outcomes in the offspring affected by PNS.
Intergenerational crosstalk of brain-gut axis in parental NdO exposure-induced offspring neurotoxicity and cognitive dysfunction: a mechanistic study.
Front Public Health
November 2024
Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China.
Introduction: Rare earth elements (REEs) are widely used in plenty of fields. REEs have significant neurotoxicity and it may adversely affect the development of cognitive. For example, neodymium will causing neurological damage through penetrate the blood-brain barrier (BBB).
View Article and Find Full Text PDFSynbiotics, a promising approach for alleviating exacerbated allergic airway immune responses in offspring of a preclinical murine pollution model.
Environ Toxicol Pharmacol
December 2024
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands; Danone Nutricia Research, Utrecht, Netherlands. Electronic address:
Article Synopsis
- - The study investigates how synbiotic supplements can help reduce allergic asthma symptoms in offspring exposed to environmental cigarette smoke and house-dust mites.
- - Researchers found that pups from mothers exposed to cigarette smoke had increased lung resistance and elevated immune markers, indicating worse asthma symptoms, but synbiotics helped improve these conditions.
- - By promoting healthy gut bacteria, synbiotic intervention in early life showed promise in reducing allergic reactions and suggests a potential strategy for preventing allergies in children affected by pollution.
Maternal probiotic supplementation protects against PBDE-induced developmental, behavior and metabolic reprogramming in a sexually dimorphic manner: Role of gut microbiome.
Arch Toxicol
January 2025
Department of Molecular Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Article Synopsis
- - PBDEs, used as flame retardants, are harmful pollutants that disrupt endocrine function and alter neurobehavior and metabolism, especially during development.
- - A study tested if maternal probiotic supplementation with Limosilactobacillus reuteri could protect offspring against negative effects caused by PBDE exposure, focusing on gut microbiome diversity and developmental health.
- - Results showed that maternal LR supplementation improved gut microbiome health and developmental outcomes in PBDE-exposed offspring, leading to normalized body weight gain and corrected timing of tooth eruption in both sexes.
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