Part 1 of this article demonstrated that knowledge of coating science is important in the formulation and early development of a functionally active coating for a medical device/combination product. Part II focuses on the testing challenges and verification of the finished coating on the product.
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Metagenome-guided culturomics for the targeted enrichment of gut microbes.
Nat Commun
January 2025
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark Kgs., Lyngby, Denmark.
The gut microbiome significantly impacts human health, yet cultivation challenges hinder its exploration. Here, we combine deep whole-metagenome sequencing with culturomics to selectively enrich for taxa and functional capabilities of interest. Using a modified commercial base medium, 50 growth modifications were evaluated, spanning antibiotics, physico-chemical conditions, and bioactive compounds.
View Article and Find Full Text PDFData characterizing a panel of biodegradable cross-linked polyester implants for sustained delivery of an anti-viral drug.
Data Brief
February 2025
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto M5S 3M2, Canada.
Tenofovir alafenamide (TAF) is currently administered orally to patients for treatment of chronic hepatitis B virus infection and as a part of a combination therapy for human immunodeficiency virus (HIV) infection. A long-acting delivery system could provide several advantages as a formulation strategy for this drug including improved patient adherence, convenience, more consistent drug levels and potentially fewer side effects. To date, the vast majority of polymer-based long-acting delivery systems have been prepared from poly(lactide--glycolide) [1].
View Article and Find Full Text PDFMathematical modeling and QSPR analysis of hepatitis treatment drugs through connection indices an innovative approach.
Heliyon
January 2025
Department of Mathematics, Faculty of Sciences, Ghazi University, Dera Ghazi Khan, 32200, Pakistan.
Chemical structures may be defined based on their topology, which allows for the organization of molecules and the representation of new structures with specific properties. We use topological indices, which are precise numerical measurements independent of structure, to measure the bonding arrangement of a chemical network. An essential objective of studying topological indices is to collect and alter chemical structure data to develop a mathematical relationship between structures and physico-chemical properties, bio-activities, and associated experimental factors.
View Article and Find Full Text PDFPosition-Dependent Effects of AP Sites Within an Promoter G-Quadruplex Scaffold on Quadruplex Stability and Repair Activity of the APE1 Enzyme.
Int J Mol Sci
January 2025
A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Apurinic/apyrimidinic (AP) sites are endogenous DNA lesions widespread in human cells. Having no nucleobases, they are noncoding and promutagenic. AP site repair is generally initiated through strand incision by AP endonuclease 1 (APE1).
View Article and Find Full Text PDFViroids and Retrozymes: Plant Circular RNAs Capable of Autonomous Replication.
Plants (Basel)
December 2024
A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992 Moscow, Russia.
Among the long non-coding RNAs that are currently recognized as important regulatory molecules influencing a plethora of processes in eukaryotic cells, circular RNAs (circRNAs) represent a distinct class of RNAs that are predominantly produced by back-splicing of pre-mRNA. The most studied regulatory mechanisms involving circRNAs are acting as miRNA sponges, forming R-loops with genomic DNA, and encoding functional proteins. In addition to circRNAs generated by back-splicing, two types of circRNAs capable of autonomous RNA-RNA replication and systemic transport have been described in plants: viroids, which are infectious RNAs that cause a number of plant diseases, and retrozymes, which are transcripts of retrotransposon genomic loci that are capable of circularization due to ribozymes.
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