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Ischemic Myocardium Targeting Peptide-Guided Nanobubbles for Multimodal Imaging and Treatment of Coronary Microvascular Dysfunction.
Adv Healthc Mater
January 2025
Department of Ultrasound, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Coronary microvascular dysfunction (CMD) refers to clinical symptoms caused by structural and functional damage to coronary microcirculation. The timely and precise diagnosis of CMD-related myocardial ischemia is essential for improving patient prognosis. This study describes a method for the multimodal (fluorescence, ultrasonic, and photoacoustic) noninvasive imaging and treatment of CMD based on ischemic myocardium-targeting peptide (IMTP)-guided nanobubbles functionalized with indocyanine green (IMTP/ICG NBs) and characterizes their basic characteristics and in vitro imaging and targeting abilities.
View Article and Find Full Text PDFKey Structural Features of Microvascular Networks Leading to the Formation of Multiple Equilibria.
Bull Math Biol
January 2025
Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Woodstock Rd, Oxford, Oxfordshire, OX2 6GG, UK.
We analyse mathematical models of blood flow in two simple vascular networks in order to identify structural features that lead to the formation of multiple equilibria. Our models are based on existing rules for blood rheology and haematocrit splitting. By performing bifurcation analysis on these simple network flow models, we identify a link between the changing flow direction in key vessels and the existence of multiple equilibria.
View Article and Find Full Text PDFPrognostic role of con-/discordant coronary flow reserve and microvascular resistance in coronary microvascular disease: a systematic review and network meta-analysis.
Open Heart
January 2025
Department of Cardiology, Leiden University Medical Center, Leiden, Zuid-Holland, The Netherlands
Background: Coronary microvascular disease (CMD) is defined as impaired coronary flow reserve (CFR) and/or increased microvascular resistance (MR) without significant epicardial coronary stenosis. This definition allows for discordant CFR and MR values within patients with CMD. The aim of this meta-analysis is to characterise the prognostic value and pathophysiological backgrounds of CFR and MR con-/discordance.
View Article and Find Full Text PDFPrediction of cardiac remodeling and myocardial fibrosis in athletes based on IVIM-DWI images.
iScience
January 2025
Department of Radiology, The Affiliated Hospital of Southwest Medical University, 25# Tai Ping Street, Luzhou, Sichuan 646000, China.
Myocardial microcirculation in athletes and its relationship with cardiac remodeling (CR) and myocardial fibrosis (MF) are not fully understood. We prospectively enrolled 174 athletes and 54 healthy sedentary controls for intravoxel incoherent motion (IVIM) diffusion-weighted imaging of cardiac magnetic resonance imaging. Athletes exhibited significantly lower fast apparent diffusion coefficient (ADC) and perfusion fraction (f) in 16 myocardial segments and each blood supply area compared to controls ( < 0.
View Article and Find Full Text PDFQuantitative assessment of transmural remission in Crohn's disease using low dose computed tomography (CT) enterography perfusion imaging: a single-centre study based on intestinal microcirculation.
Clin Radiol
December 2024
Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China. Electronic address:
Aim: To assess transmural remission in patients with Crohn's disease using low-dose small bowel computed tomography (CT) perfusion scans.
Materials And Methods: Forty six patients were divided into active and remission phases based on Crohn's Disease Activity Index (CDAI) and C-reactive protein (CRP). Dual-source CT enterography with low-dose perfusion scans was conducted to generate perfusion parameter maps, including blood flow (BF), blood volume (BV), time to peak (TTP), mean transit time (MTT), and permeability of surface (PS).
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