AI Article Synopsis

  • The study analyzed how glucose uptake in the brains of Balb/c mice changed over time after sensory training in a radial maze.
  • Increased glucose labeling was observed just 5 minutes after training on Day 1, particularly in key brain regions like the hippocampus and cortex.
  • However, on Day 9, while there was still an increase in glucose uptake at the 5-minute mark, this was followed by a steady decrease over the next 3 hours, indicating a potential change in metabolic response due to repeated training.

Article Abstract

Regional mapping of relative (14C)-glucose (GLU) uptake was analyzed in Balb/c mice at 3 time intervals (5 min., 1 hr., 3 hrs.) after either the first (Day 1) or the last (Day 9) daily sessions of a spatial discrimination testing procedure in an eight-arm radial maze. On Day 1, increased labelling was found 5 min. post-training in subcortical, hippocampal and cortical regions. Decreased GLU uptake was observed 1 hr. later in the same regions, followed at 3 hrs. post-training by a retarded activation in the above areas and particularly in thalamic and cortical structures. On Day 9, there was only an early (5 min.) post-training increase in metabolic activity followed by a subsequent monotonic decrease over 3 hrs. post-training period.

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