Regional mapping of relative (14C)-glucose (GLU) uptake was analyzed in Balb/c mice at 3 time intervals (5 min., 1 hr., 3 hrs.) after either the first (Day 1) or the last (Day 9) daily sessions of a spatial discrimination testing procedure in an eight-arm radial maze. On Day 1, increased labelling was found 5 min. post-training in subcortical, hippocampal and cortical regions. Decreased GLU uptake was observed 1 hr. later in the same regions, followed at 3 hrs. post-training by a retarded activation in the above areas and particularly in thalamic and cortical structures. On Day 9, there was only an early (5 min.) post-training increase in metabolic activity followed by a subsequent monotonic decrease over 3 hrs. post-training period.
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Proc Natl Acad Sci U S A
February 2025
Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218.
The hippocampal dentate gyrus (DG) is thought to orthogonalize inputs from the entorhinal cortex (pattern separation) and relay this information to the CA3 region. In turn, attractor dynamics in CA3 perform a pattern completion or error correction operation before sending its output to CA1. In a mouse model of congenital hypoplasia of the DG, a deficiency in the (Wls) gene, specifically in cells expressing , which targets neuronal progenitors, led to an almost total absence of dentate granule cells and modestly impaired performance in spatial tasks.
View Article and Find Full Text PDFArq Bras Oftalmol
January 2025
Research Nucleus in Neuroscience and Behavior and Applied Neuroscience, Universidade de São Paulo, São Paulo, SP, Brazil.
Purpose: Amblyopia is a cortical neurological disorder caused by abnormal visual experiences during the critical period for visual development. Recent works have shown that, in addition to the well-known visual alterations, such as changes in visual acuity, several perceptual aspects of vision are affected. This study aims to analyze and compare the effects of different types of amblyopia on visual color processing and determine whether these effects are correlated with visual acuity.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
January 2025
Division of Marine and Freshwater Biology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
This study delves into the Molluscan diversity along the Gujarat coast, India, focusing on the distribution and habitat suitability of four key species: Cerithium caeruleum, Lunella coronata, Peronia verruculata, and Trochus radiatus. Utilizing species distribution models (SDMs) integrated with machine learning algorithms, we assessed the impact of environmental variables on the distribution patterns of these molluscs. Our findings reveal a nuanced understanding of habitat preferences, highlighting the critical roles of salinity, chlorophyll concentration, and water temperature.
View Article and Find Full Text PDFSci Rep
January 2025
School of Information Engineering, Tianjin University of Commerce, Tianjin, China.
Deep learning is a double-edged sword. The powerful feature learning ability of deep models can effectively improve classification accuracy. Still, when the training samples for each class are limited, it will not only face the problem of overfitting but also significantly affect the classification result.
View Article and Find Full Text PDFJ Anim Ecol
January 2025
Ecology & Evolutionary Biology, School of Biosciences, University of Sheffield, Sheffield, UK.
The evolution of sociality is one of the major evolutionary transitions in the history of life and a key step in this transition is the occurrence of kin associations. Yet, the question of what demographic processes and environmental factors generate kin-structured populations and drive kin-directed cooperation remains open. In this review, we synthesise 30 years of studies of the long-tailed tit Aegithalos caudatus, which has a kin-selected cooperative breeding system with redirected help: failed breeders may help to raise offspring of conspecifics, typically relatives, breeding nearby.
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