Purpose: Orbital manifestations of non-Hodgkin's lymphoma (NHL) are rare and accounts for only 1% of all cases of NHL. There have been no reports of treating orbital lymphoma using intensity-modulated radiotherapy (IMRT).
Materials And Methods: Four patients were treated at our institution for orbital lymphoma using IMRT. Radiotherapy (RT) plans using wedged pair fields were developed for comparison. Clinical results using IMRT are presented and a dosimetric analysis between IMRT and RT was performed.
Results: All patients had a complete response based on their physical examinations and post-IMRT imaging. Symptoms that had been present at initial presentation resolved in all patients during the course of the treatment. All four patients experienced only grade 1 dry eye syndrome and keratitis. The average dose to the contralateral orbit, lacrimal gland, and lens were all significantly reduced (P < 0.01) in IMRT patients as compared to the RT patients. IMRT reduced the V5 and V10 for the contralateral lens, orbit, and lacrimal gland and the optic chiasm (P < 0.05).
Conclusion: IMRT is feasible when treating orbital lymphoma and reduces dose to critical structures while providing excellent dose coverage of target volumes. IMRT offers patients with orbital lymphoma excellent clinical outcomes, similar to conventional RT, with no increased toxicity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11604-008-0276-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Orbital Lymphoma Presenting As Recurrent Orbital Cellulitis: A Diagnostic Challenge.
Cureus
October 2024
Department of Ophthalmology, Hospital Sultanah Bahiyah, Alor Setar, MYS.
Orbital cellulitis is an infection of the orbital tissue behind the orbital septum. We report a case of a 71-year-old Malay lady, a passive smoker for 20 years, presenting with recurrent orbital cellulitis at the same site. She initially presented with right periorbital swelling, redness, and reduced vision worsening over two weeks, along with a firm swelling over the right temple.
View Article and Find Full Text PDFThe Role of Radiotherapy in Indolent Ocular Adnexal and Orbital Lymphomas.
Head Neck
November 2024
Faculty of Medicine, Department of Radiation Oncology, Hacettepe University, Ankara, Turkey.
Background: This study evaluates the oncological outcomes and toxicities of indolent ocular adnexal and orbital lymphomas (OOLs) treated with radiotherapy (RT) ± systemic therapy.
Methods: A retrospective analysis of 44 patients with indolent OOLs treated with RT was conducted.
Results: Most patients (87%) had early-stage disease.
Diffuse preretinal infiltrates in a patient with orbital atypical T-cell lymphoproliferative infiltration masquerading posterior uveitis.
GMS Ophthalmol Cases
September 2024
Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Article Synopsis
- A 25-year-old woman displayed aggressive symptoms of atypical T-cell lymphoproliferative infiltration, starting with preretinal infiltrates that mimicked uveitis.
- The patient's condition deteriorated, leading to severe complications, including bilateral proptosis and other neurological signs.
- The case highlights that T-cell lymphoproliferative disease can present in unusual ways and should be considered in patients showing unusual ocular symptoms.
Evaluation of the specificity of trigeminal nerve enlargement in the diagnosis of IgG4-related ophthalmic disease.
Jpn J Ophthalmol
November 2024
Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
Purpose: Enlargement of the trigeminal nerve is observed in 20-53% of patients with IgG4-related ophthalmic disease (IgG4-ROD) and is known to be a useful finding for the diagnosis of IgG4-ROD. On the other hand, enlargement of the trigeminal nerve has also been found at a certain frequency in orbital lymphoproliferative diseases other than IgG4-ROD. Therefore, we here re-evaluated the specificity of trigeminal nerve enlargement in the diagnosis of IgG4-ROD.
View Article and Find Full Text PDFOcular adnexal lymphoma - a retrospective study and review of the literature.
Radiol Oncol
September 2024
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Background: To review the characteristics of all Slovenian patients with ocular adnexal lymphoma (OAL) in the period of 24 years with the aim of evaluating demographic data, lymphoma location and type, disease stage, treatment modality, local control rate and survival rate.
Patients And Methods: All patients with histologically diagnosed OAL in the main tertiary centre of Slovenia, Eye Hospital, University Medical Centre Ljubljana, who were treated at Institute of Oncology Ljubljana were included in the study. Patients' data were collected from October 1995 through April 2019.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!