Objective: To investigate the dosage consistency of botulinum toxin injections in patients with long-term treatment for laryngeal dystonia.
Study Design: Chart review.
Subjects And Methods: Patients with laryngeal dystonia who had received at least 20 injections to the thyroarytenoid muscle were selected. Change of botulinum toxin dose, patient-reported effective weeks, and intervals between injections were investigated; data from the first five injections were excluded to eliminate initial dose titration.
Results: Fifty-five patients with an average follow-up of 12.5 years were identified. Mean dose of botulinum toxin was 2.37 +/- 1.6 U at the sixth injection; there was a decrease in mean dose over time, which became statistically significant at the 13th injection with a mean dose of 2.02 +/- 1.16 U. Mean duration of good effect and treatment intervals showed no significant change over time.
Conclusion: Botulinum toxin dose needed for a constant response in treatment of laryngeal dystonia decreases over time, without any accompanying change in effective weeks and intervals.
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