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Neurosarcoidosis, particularly in the absence of extra-neurologic systemic manifestations of sarcoidosis, is a challenging diagnosis that has a wide array of presentations. Most often presenting with cranial neuropathies, basilar meningitis or pituitary/hypothalamic dysfunction, isolated involvement of the spinal cord without cranial manifestations is exceptionally rare, often involving intramedullary lesions. Here, we present the unique case of a 64-year-old female with atypical neurosarcoidosis presenting with myelopathy from extra-dural nodules without other neurologic or systemic symptoms.
View Article and Find Full Text PDFA rare case of spinal myeloid sarcoma.
Surg Neurol Int
November 2024
Limburg Clinical Research Centre (LCRC), University of Hasselt, Hasselt, Belgium.
Background: Myeloid sarcoma (MS), a rare extramedullary tumor composed of myeloid blast cells, is classified by the World Health Organization as a subtype of acute myeloid leukemia (AML). Isolated, primary, or nonleukemic MS has an incidence of 2/1,000,000 adults and constitutes only 0.7% of all AML cases.
View Article and Find Full Text PDFMixed-phenotype leukemia with TCF3::ZNF384 fusion presenting as an isolated mediastinal mass.
Ann Hematol
November 2024
Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, the University of Hong Kong, Pok Fu Lam, Hong Kong.
Acute leukemia with TCF3::ZNF384 is a distinct type of acute leukemia that present most commonly as B-acute lymphoblastic leukemia or mixed-phenotype acute leukemia (B/myeloid). We report the first case of TCF3::ZNF384 mixed-phenotype leukemia presenting as isolated extramedullary disease in the mediastinum. Diagnosis using RNA-sequencing and whole genome sequencing on the primary issue is illustrated.
View Article and Find Full Text PDFMyeloid Sarcoma: Novel Advances Regarding Molecular Pathogenesis, Presentation and Therapeutic Options.
J Clin Med
October 2024
Thalassemia and Sickle Cell Disease Unit, Department of Hematology, 1st Department of Internal Medicine, General Hospital of Larissa, Tsakalov Str. 1, 41 221 Larissa, Greece.
Myeloid sarcoma (MS), an extramedullary form of acute myeloid leukemia (AML) is a rare tumor mass of myeloid blasts. It can disseminate to any one or multiple anatomical sites, with (synchronous MS) or without (isolated MS) bone marrow (BM) involvement. The aim of this review is to describe the most recent advances in MS regarding diagnosis, molecular background, various clinical manifestations from several organs, and treatment approaches.
View Article and Find Full Text PDF[Clinical features and long-term prognostic analysis of relapsed pediatric acute lymphoblastic leukemia].
Zhonghua Er Ke Za Zhi
November 2024
Department of Pediatric Hematology and Oncology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin Institutes of Health Science, Tianjin 300020, China.
Article Synopsis
- The study focuses on the clinical traits and long-term outcomes of children with relapsed acute lymphoblastic leukemia (ALL) who were treated under the CCLG-ALL 2008 protocol between 2008 and 2015.
- Data from 217 children, including age at initial diagnosis and time to relapse, were analyzed to determine overall and event-free survival rates.
- Findings revealed a 5-year overall survival rate of 37% and an event-free survival rate of 26%, with significant differences in outcomes based on relapse timing and site, as well as risk classification.
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