Objectives: To profile the presentation and management of patients seen at a velopharyngeal insufficiency (VPI) clinic and to explore the role of commonly used investigations in the workup of VPI.
Design: Retrospective review.
Setting: Tertiary care VPI clinic.
Methods: A computerized database created at the time of patient assessment was accessed to review 75 patients seen over an 18-month span.
Main Outcome Measures: Descriptive analysis of patient demographics, presenting complaints, pathophysiology, and treatment. The incidence of chromosome 22q microdeletion in patients presenting to such a clinic was also determined.
Results: The most common etiology was persistent VPI following prior cleft palate surgery. Eleven percent of presenting patients were identified with 22q microdeletion by fluorescent in situ hybridization testing.
Conclusions: VPI is the result of a wide number of etiologies, with a high incidence of 22q microdeletion identified. Routine genetic testing in VPI clinics is advocated.
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