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Raster Scan optoacoustic Mesoscopy for detecting microvascular complications in diabetes mellitus: A narrative brief review.
Diabetes Res Clin Pract
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Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Diabetes mellitus (DM) may lead to microvascular and macrovascular complications. Screening for these complications is crucial and non-invasive methods with high-dissemination potential are needed. Diabetic peripheral neuropathy (DPN) is particularly challenging to screen due to the lack of reliable clinical markers and endpoints.
View Article and Find Full Text PDFThe Aging Substantia Nigra is Characterized by ROS Accumulation Potentially Resulting in Increased Neuroinflammation and Cytoskeletal Remodeling.
Adv Biol (Weinh)
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Medizinisches Proteom-Center, Medical Faculty, Ruhr-University Bochum, 44801, Bochum, Germany.
Aging is a progressive and irreversible process, serving as the primary risk factor for neurodegenerative disorders. This study aims to identify the molecular mechanisms underlying physiological aging within the substantia nigra, which is primarily affected by Parkinson's disease, and to draw potential conclusions on the earliest events leading to neurodegeneration in this specific brain region. The characterization of essential stages in aging progress can enhance knowledge of the mechanisms that promote the development of Parkinson's disease.
View Article and Find Full Text PDFRadionuclide-activated luminescence for cancer theranostics.
Chemistry
March 2025
Peking Union Medical College Hospital, Department of Nuclear Medicine, No.1 Shuaifuyuan Wangfujing Dongcheng District, 100730, Beijing, CHINA.
Within dielectric media, charged particles emitted from medical radionuclides induce polarization of surrounding molecules, which subsequently generate Cerenkov luminescence (CL) upon returning to their ground state. This CL emission confers clinically approved radiotracers with distinctive potential for applications in phototheranostics. However, the utility of CL in vivo has been severely constrained by its ultraviolet-weighted emission spectrum and extremely low photon flux, particularly in living imaging and triggering photodynamic therapy.
View Article and Find Full Text PDFThermal Protection Techniques for Image-guided Musculoskeletal Ablation.
Radiographics
April 2025
From the Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Washington, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105 (P.C.T., A.A., A.P., E.A., N.H., M.C.); Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Colorado Anschutz Medical Campus, Aurora, Colo (C.K.H.); and Department of Radiology, Penn State Health, Hershey, Pa (L.M.S.).
Percutaneous image-guided thermal ablation has gained wide acceptance among physicians for the treatment of benign and malignant tumors of the musculoskeletal system. Increasing evidence to support the efficacy of thermal ablation techniques in primary and adjuvant treatment of soft-tissue sarcomas, treatment of oligometastatic disease to bone and soft tissue, and metastatic pain palliation has positioned interventional oncology alongside surgery, systemic therapies, and radiation therapy as the fourth pillar of modern comprehensive cancer care. Despite the expanding indications and increasing use in clinical practice, thermal ablation carries a significant risk of injury to the adjacent vulnerable structures, predominantly the skin, bowel, and neural structures.
View Article and Find Full Text PDFToward spatial glycomics and glycoproteomics: Innovations and applications.
BBA Adv
February 2025
Molecular and Cellular Glycoproteomics Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8565, Japan.
In this mini review, we provide an overview of the challenging field of spatial glycomics/glycoproteomics. Owing to their complexity, sophisticated analytical methods and innovative technologies are needed to advance this field. An agile development approach enables unraveling aberrant glycosylations, glycobiomarkers, and glycotargets for spatial imaging, diagnosis, and therapeutic purposes.
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