Objective: The present study examined whether threat-related selective attention was predictive of treatment success in children with anxiety disorders and whether age moderated this association. Specific components of selective attention were examined in treatment responders and nonresponders.
Method: Participants consisted of 131 children with anxiety disorders (aged 8-16 years), who received standardized cognitive-behavioral therapy. At pretreatment, a pictorial dot-probe task was administered to assess selective attention. Both at pretreatment and posttreatment, diagnostic status of the children was evaluated with a semistructured clinical interview (the Anxiety Disorders Interview Schedule for Children).
Results: Selective attention for severely threatening pictures at pretreatment assessment was predictive of treatment success. Examination of the specific components of selective attention revealed that nonresponders showed difficulties to disengage their attention away from severe threat. Treatment responders showed a tendency not to engage their attention toward severe threat. Age was not associated with selective attention and treatment success.
Conclusions: Threat-related selective attention is a significant predictor of treatment success in children with anxiety disorders. Clinically anxious children with difficulties disengaging their attention away from severe threat profit less from cognitive-behavioral therapy. For these children, additional training focused on learning to disengage attention away from anxiety-arousing stimuli may be beneficial.
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http://dx.doi.org/10.1097/CHI.0b013e31819176e4 | DOI Listing |
Cancer Treat Rev
January 2025
Gastrointestinal Unit, Department of Medicine, Royal Marsden Hospital, London and Surrey, UK. Electronic address:
Claudins (CLDNs) play a crucial and indispensable role as fundamental components within the structure of tight junctions. Due to the distinct and unique distribution pattern exhibited by CLDNs in both normal and malignant tissues, these proteins have garnered significant attention as pivotal targets for systemic anti-cancer therapy and as noteworthy diagnostic markers. This review provides a comprehensive and detailed elucidation of the fundamental understanding surrounding CLDNs, their intricate expression patterns, the potential role they play in cancer diagnosis and therapeutic potentials; all encapsulated within a succinct summary of the cutting-edge advancements and the information derived from various clinical trials.
View Article and Find Full Text PDFNanotechnology
January 2025
Qingdao University, Ningxia Road 308, Qingdao, Shandong, 266071, CHINA.
Graphitic carbon nitride (g-C3N4) has gained significant attention as a promising nonmetallic semiconductor photocatalyst due to its photochemical stability, favorable electronic properties, and efficient light absorption. Nevertheless, its practical applications are hindered by limitations such as low specific surface area, rapid recombination of photogenerated charge carriers, poor electrical conductivity, and restricted photo-response ranges. This review explores recent advancements in the synthesis, modification and application of g-C3N4 and its nanocomposites with a focus on addressing these challenges.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.
Combination therapies using checkpoint inhibitors with immunostimulatory agonists have attracted great attention due to their synergistic therapeutic effects for cancer treatment. However, such combination immunotherapies require specific timing of doses to show sufficient antitumor efficacy. Sequential treatment usually requires multiple administrations of the individual drugs at specific time points, thus increasing the complexity of the drug regimen and compromising patient compliance.
View Article and Find Full Text PDFHolist Nurs Pract
January 2025
Author Affiliations: Department of Nursing, Faculty of Health Sciences, Adıyaman University, Adıyaman, Türkey.
Cupping therapy is an ancient traditional and complementary treatment practice. Cupping therapy has recently attracted global attention in the promotion, protection, and treatment of health. Research is also being conducted on the potential benefits of cupping therapy in the treatment of conditions related to women's health.
View Article and Find Full Text PDFOccup Med (Lond)
January 2025
NHS Practitioner Health, 18 Wandsworth Rd, London SW8 2JB, UK.
Background: There is growing interest in understanding neurodevelopmental disorders such as Attention-deficit/hyperactivity disorder (ADHD) among doctors. However, the current understanding of ADHD and its association with mental well-being in doctors is limited.
Aims: This study investigated the significance of ADHD among doctors with mental health difficulties accessing a national mental health service for doctors in England.
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