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Hemophagocytic lymphohistiocytosis in early pregnancy: A rare and fatal diagnostic challenge.
Obstet Med
January 2025
Intensive Care and Obstetric Research Group (GRICIO), Universidad de Cartagena, Cartagena, Colombia.
Objective: This report details the complexities of diagnosing and treating rapid-onset multisystemic hemophagocytic lymphohistiocytosis (HLH) during pregnancy, as evidenced by a fatal case in early pregnancy with severe hematological and obstetric complications.
Case Presentation: A 20-year-old pregnant woman in her second pregnancy presented at 8 weeks of gestation with abdominal pain, fever, and rectal bleeding. Laboratory tests revealed leukopenia, thrombocytopenia, and anemia, leading to immediate transfusion and intensive care unit admission.
Rapid Neurological Decline due to Creutzfeldt-Jakob Disease.
J Community Hosp Intern Med Perspect
January 2025
Creutzfeldt-Jakob Disease (CJD) is an exceedingly rare condition with an incidence of one case per million people worldwide. It is diagnosed with symptoms of rapid neurological decline, positive CSF biomarkers, and diagnostic findings on MRI and EEG. There is no known effective therapy for CJD and prompt diagnosis is required to prepare for the expected disease prognosis and goals of care discussions.
View Article and Find Full Text PDFTransverse Myelitis in a Healthy Patient With Benign Paroxysmal Positional Vertigo: A Case Report Highlighting Inpatient Rehabilitation and Functional Gains.
Cureus
December 2024
Physical Medicine and Rehabilitation, San Joaquin Valley Rehabilitation Hospital, Fresno, USA.
Transverse myelitis (TM), a poorly understood neurological disorder, can manifest in various clinical scenarios. We report a unique case where TM presented in a background of benign paroxysmal positional vertigo (BPPV). The patient, an otherwise healthy female, experienced a rapid onset of symptoms, culminating in complete left-sided hemiparesis and exacerbation of BPPV characteristics.
View Article and Find Full Text PDFKey personal insights and changing needs of osteoarthritis patients: an international quantitative survey analysis.
Reumatologia
December 2024
Óbuda University, Budapest, Hungary.
Introduction: Osteoarthritis (OA) presents significant challenges, imposing limitations on patients' daily activities. Factors such as restricted mobility, sedentary lifestyles, social isolation, and weight gain can exacerbate the difficulties faced by these individuals. Our study aimed to identify the needs and personal challenges faced by individuals with OA, and the impact of the COVID-19 pandemic.
View Article and Find Full Text PDFMetabolomic Profiles of Siberian Wood Frog in Hypoxia and Upon Reoxygenation.
Biochemistry (Mosc)
December 2024
Institute of the Biological Problems of the North, Far Eastern Branch of the Russian Academy of Sciences, Magadan, 630058, Russia.
Hypoxia poses a serious challenge for all animals; however, certain animals exhibit a remarkable resilience in the case of prolonged and severe hypoxia. The Siberian wood frog is a unique amphibian capable of surviving for up to several months at almost complete anoxia. We investigated changes in the metabolome of at the onset of hypoxia (day 1) and within 1 h of reoxygenation after a long-term hypoxia using H NMR.
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