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The relationship between fractional amplitude of low-frequency fluctuations (fALFF) and the severity of neglect in patients with unilateral spatial neglect (USN) after stroke: A functional near-infrared spectroscopy study.
IBRO Neurosci Rep
June 2025
Rehabilitation Clinic, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China.
Objective: Unilateral spatial neglect (USN) following right hemisphere stroke is more pronounced, severe, and persistent than in the left hemisphere. However, the pathophysiological mechanisms underlying USN remain largely unknown. This study aims to investigate the relationship between the fractional amplitude of low-frequency fluctuations (fALFF) in the right hemisphere of patients with post-stroke USN and the severity of neglect using resting-state functional near-infrared spectroscopy (fNIRS) technology.
View Article and Find Full Text PDFExpert Clinical Management of Inflammatory Immune-Related Arthritis in Patients with Cancer Receiving Immune Checkpoint Inhibitors.
J Immunother Precis Oncol
February 2025
Department of Health Services and Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Introduction: Treatment guidelines for immune-related inflammatory arthritis (irAE-IA) in patients with cancer receiving immune checkpoint inhibitors (ICIs) are vague with respect to the use of specific agents. Patients are usually referred to rheumatologists for treatment. We conducted a survey of expert rheumatologists to determine current practices.
View Article and Find Full Text PDFPeripheral blood biomarkers as differential diagnostic markers of disease severity in neonates with hyperbilirubinemia.
Heliyon
January 2025
Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Background: Blood biomarkers offers an independent insight for the pathophysiology of hyperbilirubinemia. However, they are not practically used for the differential diagnosis of the hyperbilirubinemia severity. Therefore, the current study aimed to assess the differential diagnostic value of peripheral blood biomarkers with disease severity as an alternative.
View Article and Find Full Text PDFPrecision medicine in gynecological cancer (Review).
Biomed Rep
March 2025
Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
The advent of personalized and precision medicine has revolutionized oncology and treatment of gynecological cancer. These innovative approaches tailor treatments to individual patient profiles beyond genetic markers considering environmental and lifestyle factors, thereby optimizing therapeutic efficacy and minimizing adverse effects. Precision medicine uses advanced genomic technologies such as next-generation sequencing to perform comprehensive tumor profiling.
View Article and Find Full Text PDFThe interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity.
J Neuroinflammation
January 2025
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
The thrombolytic protease tissue plasminogen activator (tPA) is expressed in the CNS, where it regulates diverse functions including neuronal plasticity, neuroinflammation, and blood-brain-barrier integrity. However, its role in different brain regions such as the substantia nigra (SN) is largely unexplored. In this study, we characterize tPA expression, activity, and localization in the SN using a combination of retrograde tracing and β-galactosidase tPA reporter mice.
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