Study Design: Retrospective study.
Objective: To evaluate the radiological results of fusion with segmental pedicle screw fixation in juvenile idiopathic scoliosis with a minimum 5-year follow-up.
Summary Of Background Data: Progression of spinal deformity after posterior instrumentation and fusion in immature patients has been reported by several authors. Segmental pedicle screw fixation has been shown to be effective in controlling both coronal and sagittal plane deformities. However, there is no long term study of fusion with segmental pedicle screw fixation in these group of patients.
Methods: Seven patients with juvenile idiopathic scoliosis treated by segmental pedicle screw fixation and fusion were analyzed. The average age of the patients was 7.4 years (range 5-9 years) at the time of the operation. All the patients were followed up 5 years or more (range 5-8 years) and were all Risser V at the most recent follow up. Three dimensional reconstruction of the radiographs was obtained and 3DStudio Max software was used for combining, evaluating and modifying the technical data derived from both 2d and 3d scan data.
Results: The preoperative thoracic curve of 56 +/- 15 degrees was corrected to 24 +/- 17 degrees (57% correction) at the latest follow-up. The lumbar curve of 43 +/- 14 degrees was corrected to 23 +/- 6 degrees (46% correction) at the latest follow-up. The preoperative thoracic kyphosis of 37 +/- 13 degrees and the lumbar lordosis of 33 +/- 13 degrees were changed to 27 +/- 13 degrees and 42 +/- 21 degrees , respectively at the latest follow-up. None of the patients showed coronal decompensation at the latest follow-up. Four patients had no evidence of crankshaft phenomenon. In two patients slight increase in Cobb angle at the instrumented segments with a significant increase in AVR suggesting crankshaft phenomenon was seen. One patient had a curve increase in both instrumented and non instrumented segments due to incorrect strategy.
Conclusion: In juvenile idiopathic curves of Risser 0 patients with open triradiate cartilages, routine combined anterior fusion to prevent crankshaft may not be warranted by posterior segmental pedicle screw instrumentation.
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http://dx.doi.org/10.1186/1748-7161-4-1 | DOI Listing |
AoB Plants
January 2025
Department of Biology, Loyola University Chicago 1032 W. Sheridan Rd. Chicago, IL 60660, United States.
The shift from outcrossing to predominantly selfing is one of the most common transitions in plant evolution. This evolutionary shift has received considerable attention from biologists; however, this work has almost exclusively been focused on animal-pollinated systems. Despite the seminal ecological and economic importance of wind-pollinated species, the mechanisms controlling the degree of outcrossing in wind-pollinated taxa remain poorly understood.
View Article and Find Full Text PDFArch Bone Jt Surg
January 2024
Department of Medical Physics and Radiology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
This study aimed to evaluate the efficacy of antibiotic-loaded cement articulating spacers produced through a silicone mold in the two-stage revision of infected total knee arthroplasty. Five individuals were prospectively treated with 2-stage revision using spacers made by this mold. Clinical assessment was conducted during and after implantation using the WOMAC Score, Oxford knee score, and range of motion (ROM).
View Article and Find Full Text PDFFront Immunol
January 2025
Immunology Research Center, National Health Research Institute, Zhunan, Taiwan.
CASK, a MAGUK family scaffold protein, regulates gene expression as a transcription co-activator in neurons. However, the mechanism of CASK nucleus translocation and the regulatory function of CASK in myeloid cells remains unclear. Here, we investigated its role in H5N1-infected macrophages.
View Article and Find Full Text PDFFront Sports Act Living
January 2025
Department of Sports Science, Sichuan University, Chengdu, China.
Background: In recent years, an increasing number of scholars have begun to focus on the relationship between children's motor development and school activities, with the relationship between children's fine motor skills and academic achievement being a particularly researched area. However, due to different research perspectives among scholars, the results in this field have been somewhat controversial. Therefore, this study aims to delve deeper into the relationship between children's fine motor skills and their various academic abilities through systematic review and meta-analysis.
View Article and Find Full Text PDFFront Oncol
January 2025
Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Introduction: Oncolytic herpes simplex viruses (oHSVs) are a type of biotherapeutic utilized in cancer therapy due to their ability to selectively infect and destroy tumor cells without harming healthy cells. We sought to investigate the functional genomic response and altered metabolic pathways of human cancer cells to oHSV-1 infection and to elucidate the influence of these responses on the relationship between the virus and the cancer cells.
Methods: Two datasets containing gene expression profiles of tumor cells infected with oHSV-1 (G207) and non-infected cells from the Gene Expression Omnibus (GEO) database were processed and normalized using the R software.
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