An alternative convenient synthesis of piperidazine-3-carboxylic acid derivatives.

Chem Pharm Bull (Tokyo)

Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.

Published: January 2009

The short-step synthesis of the unsubstituted, 5-hydroxy- and 5-chloropiperidazine-3-carboxylic acids using an aza Diels-Alder reaction between the 1,3-diene and azodicarboxylate was described. This synthetic methodology could be used for the preparation of the optically active piperazic acid in a 35% overall yield.

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Source
http://dx.doi.org/10.1248/cpb.57.49DOI Listing

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