AI Article Synopsis
- The Escherichia coli mutant lacking external polyamines exhibits abnormal growth patterns, including phases of growth arrest followed by normal growth after mutation.
- The mutant shows increased expression of SOS genes compared to the wild type, indicating a stress response.
- The duration of growth arrest is inversely related to polyamine concentration, suggesting that polyamines play a signaling role in facilitating adaptive mutations.
Article Abstract
In the absence of exogenous polyamines, the polyamine-deficient Escherichia coli mutant shows not only a characteristic dual-phase growth with abnormal growth, growth arrest, and normal growth after mutation, but also a higher expression of the SOS genes than the polyamine-proficient wild type. The interval of the growth arrest is inversely regulated in a polyamine concentration-dependent manner. These results indicate that the polyamines can act as a signal not only for provoking an adaptive mutation, but also for hastening generation of an adaptive mutation.
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| http://dx.doi.org/10.1134/s0006297908110096 | DOI Listing |
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