[Metronidazole-induced reversible cerebellar lesions and peripheral neuropathy].

Med Mal Infect

Service de médecine interne, CHU de Sahloul, route de Ceinture, Sousse, Tunisie.

Published: December 2009

Introduction: Metronidazole is a widely prescribed treatment for amoebic and anaerobic germ infections. Its neurologic toxicity is rare but can be serious.

Case Report: We report the case of a 27-year-old male patient, treated with metronidazole for a cerebral abscess. He presented with a cerebellar syndrome and peripheral neuropathy at a cumulative metronidazole dose of 60g. The MRI aspect of the cerebellar lesions in addition to their reversibility after treatment cessation led to the diagnosis of metronidazole induced neurologic toxicity.

Conclusion: The occurrence of neurologic disorders in patients treated with metronidazole must suggest drug toxicity and lead to cessation of treatment.

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Source
http://dx.doi.org/10.1016/j.medmal.2008.11.007DOI Listing

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