Most objects in our environment are organized hierarchically with a global whole embedding its local parts, but the way we recognize these features remains unclear. Using a visual masking paradigm, we examined the temporal dissociation between global and local feature as proposed in Reverse Hierarchy Theory, RHT (Ahissar & Hochstein, 2000), where global and local information are assumed to be processed, respectively, by feed-forward and feedback systems. We found that in a long Stimulus Onset Asynchrony (SOA) condition, both global and local information were recognized adequately. However, in a short SOA condition, global information was recognized correctly while local recognition was critically disrupted. Consistent with RHT, it is suggested that local information is processed in a feedback system; this processing is then interrupted by the mask stimulus presented later at the primary visual area. Global information, by contrast, is transferred via a feed-forward system, and is not disrupted by the mask.
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http://dx.doi.org/10.1080/00207450802540524 | DOI Listing |
Sci Rep
December 2024
Departamento de Física, Universidad Carlos III de Madrid, Avda. de la Universidad 30, 28911, Leganés, Spain.
Considering a universal deep neural network organized as a series of nested qubit rotations, accomplished by adjustable data re-uploads we analyze its expressivity. This ability to approximate continuous functions in regression tasks is quantified making use of a partial Fourier decomposition of the generated output and systematically benchmarked with the aid of a teacher-student scheme. While the maximal expressive power increases with the depth of the network and the number of qubits, it is fundamentally bounded by the data encoding mechanism.
View Article and Find Full Text PDFNat Commun
December 2024
Department of Natural Resources and the Environment, University of Connecticut, Storrs, CT, USA.
Converting natural vegetation to croplands alters the local land surface energy budget. Here, we use two decades of satellite data and a physics-based framework to analyse the biophysical mechanisms by which croplands influence daily mean land surface temperature (LST). Globally, 60% of croplands exhibit an annual warming effect, while 40% have a cooling effect compared to their surrounding natural ecosystems.
View Article and Find Full Text PDFNat Commun
December 2024
Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
Rabies is a viral zoonosis that kills thousands of people annually in low- and middle-income countries across Africa and Asia where domestic dogs are the reservoir. 'Zero by 30', the global strategy to end dog-mediated human rabies, promotes a One Health approach underpinned by mass dog vaccination, post-exposure vaccination of bite victims, robust surveillance and community engagement. Using Integrated Bite Case Management (IBCM) and whole genome sequencing (WGS), we enhanced rabies surveillance to detect an outbreak in a formerly rabies-free island province in the Philippines.
View Article and Find Full Text PDFNat Commun
December 2024
Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Glioblastoma is immunologically "cold" and resistant to single-agent immune-checkpoint inhibitors (ICI). Our previous study of neoadjuvant pembrolizumab in surgically-accessible recurrent glioblastoma identified a molecular signature of response to ICI and suggested that neoadjuvant pembrolizumab may improve survival. To increase the power of this observation, we enrolled an additional 25 patients with a primary endpoint of evaluating the cell cycle gene signature associated with neoadjuvant pembrolizumab and performed bulk-RNA seq on resected tumor tissue (NCT02852655).
View Article and Find Full Text PDFAnn Clin Transl Neurol
December 2024
Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, P. R. China.
Background: Variants in the GABRA2 gene, which encodes the α2 subunit of the γ-aminobutyric acid A receptor, have been linked to a rare form of developmental and epileptic encephalopathy (DEE) referred to as DEE78. Only eight patients have been reported globally. This study presents the clinical presentation and genetic analysis of a Chinese family with a child diagnosed with DEE78, due to a novel GABRA2 variant.
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