Purpose: We describe the outcomes of femoro-distal bypass procedures used to treat peripheral arterial occlusive disease (PAOD). The aim of this retrospective analysis was to evaluate primary patency and limb salvage at 5 years.
Methods And Patients: We retrospectively studied 122 consecutive patients who underwent femoro-distal bypass surgery from 1999 to 2002. Information was collected from clinical charts at S. João Hospital, Porto, Portugal. Kaplan-Meier curves were used to calculate primary patency and limb salvage rates; groups were compared using Cox proportional hazards models.
Results: Five-year cumulative primary patency was 67,1% and limb-salvage rate was 71,1%. Major amputation risk for diabetics was significantly higher - 49% - compared with 18% in non-diabetics patients (p=0,0001). There were trends associating major amputation with women and smokers; there were also trends associating hypertension and in situ saphenous vein bypass with lower risk of major amputation .
Conclusion: Our preliminary results support the view that infrainguinal revascularization can be safely performed, with acceptable five-year cumulative primary patency and major amputation rates. The risk of major amputation, however, is significantly increased in diabetic patients.
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Diabetes Metab
January 2025
Nutrition-Diabetes Department, University Hospital of Montpellier, Montpellier, France; PhyMedExp, INSERM U1046, National Centre for Scientific Research (CNRS) Joint Research Unit (UMR) 9214, University of Montpellier, Montpellier, France. Electronic address:
Objective: The out-of-hospital care pathways of people with DFU have been little studied. We used the French National Health Data System (SNDS) to collect refund and care pathway data for all French residents. The aim of this study was to determine the incidence of major lower limb amputation (MA) and associated risk factors in a population with an incident DFU.
View Article and Find Full Text PDFJ Vasc Surg
January 2025
The George Washington University Hospital, Department of Surgery, Washington, D.C., USA.
Background: Infrainguinal bypass for chronic limb-threatening ischemia (CTLI) in octogenarians is considered a high-risk procedure due to the presumed associated frailty of the patient population. However, the alternative which is major amputation may not be a better option. This study retrospectively compares the outcomes of bypass versus major amputation for functionally independent and partially dependent patients.
View Article and Find Full Text PDFJ Arthroplasty
January 2025
Department of Orthopaedic Surgery, Chang Gung Memorial Hospital (CGMH), No. 5 Fu-Hsing Street, Kweishan, Taoyuan, Taiwan; Bone and Joint Research Center, Chang Gung Memorial Hospital (CGMH), No. 5 Fu-Hsing Street, Kweishan, Taoyuan, Taiwan; College of Medicine, Chang Gung University (CGU), 259 Wen-Hwa 1st Road, Kweishan, Taoyuan, Taiwan. Electronic address:
Background: Chronic periprosthetic joint infection (PJI) presents a major challenge in knee arthroplasty, with varying success rates reported for two-stage exchange arthroplasty (EA) and a lack of consensus on managing failures from such procedures. This study evaluated repeat two-stage EA outcomes for knee PJI after initial treatment failure to identify the risk factors for reimplantation unsuitability and reinfection.
Methods: We analyzed 114 patients who underwent repeat EA for chronic knee PJI between 2010 and 2018.
Genome Res
January 2025
Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA;
Following amputation, zebrafish regenerate their injured caudal fin through lineage-restricted reprogramming. Although previous studies have charted various genetic and epigenetic dimensions of this process, the intricate gene regulatory programs shared by, or unique to, different regenerating cell types remain underinvestigated. Here, we mapped the regulatory landscape of fin regeneration by applying paired snRNA-seq and snATAC-seq on uninjured and regenerating fins.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Oral & Maxillofacial Reconstruction and Regeneration of Luzhou Key Laboratory, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou 646000, China.
Diabetic wound healing remains a major challenge in modern medicine. The persistent inflammation and immune dysfunction hinder angiogenesis by producing excessive ROS and increasing the susceptibility to bacterial infection. In this study, we developed an integrated strategy for whole-process management of diabetic wounds based on a bioinspired adhesive hydrogel platform with hemostasis, photothermal antimicrobial, antioxidant, anti-inflammatory, and angiogenic properties.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!