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Efficacy and Safety of P2Y monotherapy vs standard DAPT in patients undergoing percutaneous coronary intervention: meta-analysis of randomized trials.
Curr Probl Cardiol
August 2024
Clinical Experimental Cardiology, Clinical and Interventional Cardiology, University of Sassari, Sassari, Sardinia Island, Italy; Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy; SIRIO MEDICINE Research Network, Sassari, Italy. Electronic address:
Background: Debates persist regarding the optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in coronary artery disease (CAD). Recent trials have introduced a novel approach involving P2Y12 inhibitor monotherapy with ticagrelor or clopidogrel, after a short DAPT. However, the effectiveness and safety of this strategy remains to be established.
View Article and Find Full Text PDFAdverse perinatal outcomes in gestational diabetes mellitus with and without SARS-CoV-2 infection during pregnancy: results from two nationwide registries in Germany.
BMJ Open Diabetes Res Care
January 2024
Department of Obstetrics and Gynecology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Introduction: Pregnancy is a known independent risk factor for a severe course of COVID-19. The relationship of SARS-CoV-2 infection and gestational diabetes mellitus (GDM) on neonatal outcomes is unclear. Our aim was to determine if SARS-CoV-2 infection represents an independent risk factor for adverse perinatal outcomes in pregnancy with GDM.
View Article and Find Full Text PDFMultiple Gestation as a Risk Factor for SARS-CoV-2-Associated Adverse Maternal Outcome: Data From the COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS).
Geburtshilfe Frauenheilkd
December 2023
Gynecology and Obstetrics, University Hospital Münster, Münster, Germany.
Article Synopsis
- Pregnant women with COVID-19 face higher risks of severe complications, especially those with multiple pregnancies due to physical changes in lung function caused by the growing fetus.
- A study analyzed outcomes in 5514 women with symptomatic COVID-19 during pregnancy, focusing on the difference between those with multiple pregnancies and those with singletons.
- Results showed that while the overall incidence of adverse outcomes was similar, multiple pregnancies had earlier onset of complications and certain factors like high preconceptional BMI significantly increased risks.
SARS-CoV-2 Infection During Pregnancy.
Dtsch Arztebl Int
September 2022
Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Kiel; Center for Pediatric and Adolescent Medicine, University Hospital Gießen and Marburg GmbH, Philipps University Marburg; Department of Gynecology and Obstetrics, LMU Medical Center, Munich; Neonatology and Pediatric Intensive Care Medicine, Department of Pediatric and Adolescent Medicine, Medical Faculty, Technical University of Dresden; Center for Fetal and Neonatal Health, Technical University of Dresden; Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Johannes Kepler University, Linz, Austria; Department of Obstetrics, University Hospital Jena; Institute for Medical Informatics and Statistics, University Hospital Schleswig-Holstein, Kiel.
Background: Using data from the German CRONOS registry, we assessed the risk of a complicated course of COVID-19 in women with a SARS-CoV-2-infection during pregnancy, with particular consideration of gestational age, vaccination status, and pandemic dynamics.
Methods: Data acquired in two separate periods (March 2020 to August 2021; January to June 2022) for CRONOS, a prospective, hospital-based observational study (DRKS00021208), were studied with logistic regression models. Odds ratios comparing 32 with 22 weeks of gestation were calculated for relevant COVID-19-specific events occurring within 4 weeks of a positive test result.
Pregnancy outcomes in Japanese patients with SLE: retrospective review of 55 pregnancies at a university hospital.
Clin Rev Allergy Immunol
February 2013
Center for Rheumatic Diseases, Yokohama City University Medical Center, 4-57 Urafune-cho, Yokohama, Kanagawa 232-0024, Japan.
Systemic lupus erythematosus (SLE) is mainly a disease of fertile women and the coexistence of pregnancy is by no means a rare event. How SLE and its treatment affect pregnancy outcomes is still a matter of debate. We performed a retrospective analysis of 41 SLE patients (55 pregnancies) who were followed at our university hospital from January 2000 to December 2009.
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