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A novel method for recombinant mammalian-expressed S-HBsAg virus-like particle production for assembly status analysis and improved anti-HBs serology.
Protein Sci
January 2025
Department of Epidemiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
The Hepatitis B surface antigen (HBsAg) as the only lipid-associated envelope protein of the Hepatitis B virus (HBV) acts as cellular attachment and entry mediator of HBV making it the main target of neutralizing antibodies to provide HBV immunity after infection or vaccination. Despite its central role in inducing protective immunity, there is however a surprising lack of comparative studies examining different HBsAgs and their ability to detect anti-HBs antibodies. On the contrary, various time-consuming complex HBsAg production protocols have been established, which result in structurally and functionally insufficiently characterized HBsAg.
View Article and Find Full Text PDFOutcomes of the premarital screening program in Riyadh Region, KSA in 2021-2022: A cross-sectional study.
J Taibah Univ Med Sci
October 2024
Field Epidemiology Training Program, Deputyship of Public Health, Ministry of Health, Riyadh, KSA.
Article Synopsis
- - The study examined the prevalence of sickle cell disease, β-thalassemia, HIV, HBV, and HCV in Riyadh, Saudi Arabia, using retrospective data from a large sample of nearly 916,295 participants across two years (2021-2022).
- - A significant number of participants were affected by these conditions, with findings indicating that demographic factors, particularly sex, played a role in the prevalence of the diseases.
- - The study concluded that continuous monitoring and programs like premarital screening are essential to identify at-risk individuals and lessen the impact of these health issues, suggesting future research to track disease trends over time.
Factors Associated With Needle Stick Injuries Among Healthcare Workers: A Retrospective Study in a Tertiary Care Hospital of Eastern India.
Cureus
October 2024
Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
Article Synopsis
- Needle stick injuries (NSIs) pose serious health risks for healthcare workers, exposing them to blood-borne infections like HIV, HBV, and HCV; this study analyzed NSI cases over four years from a hospital in India.
- The study recorded 115 NSI cases from 2019 to 2022, with a higher incidence among younger healthcare workers, especially nurses in the initial years, while housekeeping staff were more affected in later years; most injuries occurred during morning shifts and in the inpatient department.
- Post-exposure prophylaxis was administered to a subset of affected workers, with a negative HIV serology status for all tested, although some cases showed positive for HBV and HCV.
Seroprevalence of HIV, HCV, and HBV: The Associated Psychiatric Co-morbidities Among Injection Drug Users in Kashmir- A Hospital-Based Cross-sectional Study.
Indian J Psychol Med
June 2024
Department of Psychiatry, Institute of Mental Health and Neurosciences, GMC Srinagar, Jammu and Kashmir, India.
Background: Injection drug use remains a significant public health concern globally, with injection drug users (IDUs) facing elevated risks of contracting blood-borne infections such as hepatitis C (HCV), hepatitis B (HBV), and acquired immune deficiency syndrome caused by the human immunodeficiency virus (HIV). This study delves into the seroprevalence of these disorders among IDUs in Kashmir and extends further to explore the relationship between injection drug use and psychiatric co-morbidities.
Methods: A cross-sectional study was conducted among IDUs recruited from tertiary care drug addiction centers.
[Strategy for early detection of viral hepatitis in patients with a request for liver biochemistry profile and hypertransaminasemia].
Semergen
October 2024
Pharmacoeconomics & Outcomes Research Iberia (PORIB), Madrid, España.
Objective: Undiagnosed viral hepatitis is an impediment to the elimination of viral hepatitis. Clinical Practice Guidelines (CPG) recommend screening in patients with hypertransaminasemia. The aim of the study was to evaluate the early detection of viral hepatitisB andC established in our health area in this population group.
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