Aim Of The Study: To investigate the relationships between serum leptin, IGF-1, insulin and bone mineral content and density in a group of Lebanese sedentary adolescent girls.
Methods And Results: Twenty Lebanese sedentary adolescent girls participated in our study. Total body bone mineral content and density were measured by dual-energy X-ray absorptiometry (DEXA). In parallel, fasting leptin, IGF-1 and insulin concentrations were also measured. Serum leptin, IGF-1 and insulin concentrations were not associated with total body bone mineral content (BMC), total body bone mineral density (BMD) or pelvis BMD.
Conclusion: Serum leptin, IGF-1 and insulin concentrations are not positive predictors of total body bone mineral content or density in this study group.
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Indian J Orthop
January 2025
Dayanand Medical College and Hospital, Tagore Nagar, civil lines, Ludhiana, Punjab 141001 India.
Purpose: There is paucity of guidelines with inadequate data available about the extent and prevention of bone and joint disease in beta-thalassemic patients in Indian population. This study aims to determine bone and joint involvement in beta-thalassemic patients. It evaluates serum biochemical parameters of bone formation and resorption and correlates with the symptomatology in these patients.
View Article and Find Full Text PDFCan J Kidney Health Dis
December 2024
Department of Medicine, Western University, London, ON, Canada.
Background: Kidney transplant recipients are uniquely exposed to the disordered bone metabolism associated with chronic kidney disease beginning before transplantation followed by chronic corticosteroid use after transplantation. Previous efforts to synthesize the rapidly accruing evidence regarding estimation and management of fracture risk in kidney transplant recipients are outdated and incomplete.
Objective: To synthesize the evidence informing the overall incidence, patient-specific risk prediction, and methods of prevention of fractures in patient living with a kidney transplant.
Cureus
November 2024
Internal Medicine, University Hospitals Birmingham NHS Trust, Birmingham, GBR.
Background: Postmenopausal women are often affected by osteoporosis, a disorder that lowers bone density, increases the risk of fractures, and has a major negative influence on quality of life.
Objective: This study aimed to assess the efficacy of bisphosphonates in reducing fracture risk among postmenopausal women with osteoporosis by analyzing their impact across various fracture sites, treatment durations, and patient subgroups.
Methodology: A retrospective cohort research was conducted between January 2021 and December 2022 at Hayatabad Medical Complex (HMC), Peshawar.
Endocr Pract
December 2024
Division of Endocrinology, Diabetes, Metabolism, and Nutrition Mayo Clinic, Rochester, MN.
People with chronic kidney disease (CKD) are at increased risk of fractures in comparison to the non-CKD population and fractures are associated with high mortality and worsening quality of life. The higher risk observed in the CKD population is related to the complex interplay of CKD-mineral bone disorder (MBD) abnormalities causing changes in bone turnover (T), mineralization (M), and volume (V), along with other risk factors accumulated as glomerular filtration rate declines. The approach for evaluation of bone disease and fracture risk in CKD is different from the approach in the general population.
View Article and Find Full Text PDFSports Med
December 2024
Ultra Sports Science Foundation, Pierre-Bénite, France.
Background: Antarctic expeditions, although supported by scientific knowledge, face various challenges, with little research conducted to explore the physical demands that explorers experience.
Objective: To summarise physiological, psychological, body composition and nutritional changes faced during trek expeditions in the Antarctic's continental portion.
Design: Systematic review.
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