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GLP-1 and its analogues: Does sex matter?
Endocrinology
December 2024
Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
While obesity and diabetes are prevalent in both men and women, some aspects of these diseases differ by sex. New blockbuster class of therapeutics, Glucagon-like peptide 1 (GLP-1) analogues (e.g.
View Article and Find Full Text PDFA higher global diet quality score is associated with lower risk of obesity among male university students in Lebanon: a pilot study.
Front Nutr
December 2024
Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon.
Objective: This pilot study aims to assess the diet quality amongst Lebanese male university students using the Global Diet Quality Score (GDQS), identify its association with obesity, and determine the key drivers of consumption of foods associated with higher NCDs risk.
Methods: A cross-sectional survey was conducted using a convenience sampling approach, comprising 385 male students aged between 18 and 24 years at the American University of Beirut. Dietary data was collected using 24-h recall, where participants detailed all foods and beverages consumed in the past 24 h, including portion sizes.
Neighborhood contributions in influencing overweight and obesity among Chinese children and adolescents: Temporal, geographical and gender variations.
Public Health
December 2024
Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China. Electronic address:
Objective: The precise extent to which neighborhood influences childhood overweight and obesity (O/O) remains unknown. We investigated the magnitudes of neighborhood contributions to childhood O/O and explored potential temporal, geographical and gender variations.
Study Design: This was a pooled analysis using secondary survey data from six China Family Panel Studies from 2010 to 2020.
Modulation of SIRT6 related signaling pathways of p-AKT/mTOR and NRF2/HO-1 by memantine contributes to curbing the progression of tamoxifen/HFD-induced MASH in rats.
Eur J Pharmacol
December 2024
Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt. Electronic address:
Metabolic dysfunction-associated steatohepatitis (MASH) is a chronic liver disorder marked by hepatic fat accumulation and inflammatory infiltrates which may evolve to cirrhosis. Clinical studies have demonstrated the higher risk of MASH development after tamoxifen (TAM) therapy, especially in obese patients. Therefore, we aimed to evaluate MASH induction by TAM combined with high fat diet (HFD) and the potential interference of memantine (MEMA) with MASH progression via modulation of SIRT6 and its related signaling pathways.
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