3-amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modifications at the quinoline 6- and 7-positions.
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| http://dx.doi.org/10.1016/j.bmcl.2008.12.046 | DOI Listing |
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