[The influence of anisodamine on cardiopulmonary resuscitation in rat].

Objective: To evaluate the influence of anisodamine (Ani) on restoration of spontaneous circulation (ROSC) and cardiopulmonary resuscitation (CPR) rate in a randomized, blinded experimental study so as to explore a new treatment for CPR.

Methods: Forty-five Sprague-Dawley (SD) rats were randomized to three groups: control group (0.9% normal saline), epinephrine (Epi) group and Epi plus Ani group (combined group), 15 rats in each group. Ventricular fibrillation (VF) or asystole was induced by transoesophageal alternating current stimulation. A blinded drug administration and mechanical chest compression were used in this study (Epi 200 microg/kg, Ani 10 mg/kg). ROSC rate and resuscitation rate were compared among these groups.

Results: Combined group had higher ROSC rate(93.3% vs. 46.7%), resuscitation rate (80.0% vs.33.3%) and survival rate within 3 hours (83.3% vs.20.0%) compared with Epi group (all P<0.05). ROSC occurred only in one rat of control group. Mean arterial pressure (MAP) at the beginning of ROSC in Epi group was higher compared with combined group (P<0.05). After ROSC, MAP decreased in both drug groups, especially after 5 minutes of ROSC, and MAP in Epi group was lower than that of combined group. There was difference between the two groups till 30 minutes after ROSC (all P<0.05) .

Conclusion: Administration of Epi plus Ani at the beginning of treatment for cardiac arrest could improve ROSC rate and resuscitation rate.