The dependence of pain sensitivity in acetic acid-induced writhing test on environmental temperature was described by a bell-shaped curve. The maximum number of writhings was observed in thermoneutral environment and minimum in hot and cold environment. Under conditions of opioid receptor blockade with naloxone, naltrindole, norbinaltorphimine, analgesia is partially mediated by micro-, delta-, and kappa-opioid receptors.
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