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The usefulness and potential of high-fidelity three-dimensional models in spine surgery training: cross-sectional empirical study.
BMC Med Educ
March 2025
Department of Orthopaedic Surgery, Dokkyo Medical University, 880, Kitakobayashi, Mibu, Shimotsuga, Tochigi, Japan.
Background: Advancements in understanding spinal disorders and diagnostic techniques have increased the range and complexity of spinal surgeries. However, constraints have arisen in gaining experience techniques through actual surgical cases due to considerations of medical safety, efficiency in working hours, and cost-effectiveness. As such, off-the-job training is expected to play an increasingly significant role.
View Article and Find Full Text PDFThe comparative efficacy of L-glutamine, celecoxib, and glucosamine sulfate in osteoarthritis management.
Sci Rep
March 2025
Department of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
To explore the therapeutic efficacy of L-glutamine (L-Gln) on pathological progression and clinical symptoms of osteoarthritis (OA), and compare with glucosamine sulfate (GS), and celecoxib (CXB). Rats were administered sodium chloride, L-Gln, GS, or CXB via gavage for eight weeks starting from the fifth week after sham operation or Anterior Cruciate Ligament Transection (ACLT) + Medial Meniscectomy (MMx). Then the severity of knee OA in rats was evaluated by serological analysis, histological examination and imaging examination.
View Article and Find Full Text PDFSuper-multiplexed imaging and coding in the range of radio frequency.
Nat Commun
March 2025
The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.
The era of the Internet has led to an information explosion, creating significant challenges for current techniques in information storage and access. High-performance strategies that expand existing methods offer a promising solution. Imaging-based approaches are vital for information perception but remain underexplored for information processing due to limited multiplexity.
View Article and Find Full Text PDFIsolated Congenital Vertebral Anomaly and Sprengel's Deformity in a WBP11 Pathogenic Variant.
Eur J Med Genet
March 2025
Department of Rehabilitation Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. Electronic address:
The pathogenic variant of WBP11 has been known as one of the various genetic causes of VACTERL syndrome. VACTERL syndrome is usually diagnosed with at least three clinical features of vertebral, heart, tracheal, esophageal, kidney, and limb anomalies. So far, only four WBP11 pathogenic variants have been documented from 13 patients, first and latest described in 2020.
View Article and Find Full Text PDFRapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replication.
Nucleic Acids Res
February 2025
Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, United States.
Regulator of telomere length 1 (RTEL1) helicase facilitates telomere replication by disassembling DNA secondary structures, such as G-quadruplexes and telomeric loops (t-loops), at the ends of the chromosomes. The recruitment of RTEL1 to telomeres occurs during the S-phase of the cell cycle, but the dynamics of the process has not been studied. Here, we utilized CRISPR genome editing and single-molecule imaging to monitor RTEL1 movement within human cell nuclei.
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