Gender- and age-related outcomes of cardiac resynchronization therapy: a pilot observational study.

Background: Cardiac resynchronization therapy (CRT) has been reported to improve clinical status and survival, and shorten hospitalization rates, in patients with heart failure (HF). However, questions remain regarding the success of CRT in different subgroups of patients with HE.

Objective: We assessed whether CRT response was related to gender or age in patients with HE.

Methods: In a longitudinal observational study, patients with severe HF (New York Heart Association [NYHA] class III or IV, left ventricular ejection fraction [LVEF] 120 ms with left bundle branch block configuration) were enrolled. Clinical electrophysiologic and echocardiographic evaluations were performed before, and 3 and 6 months after, CRT implantation.

Results: A total of 65 Iranian patients (50 men, 15 women; mean [SD] age, 60.3 [10.3] years; baseline NYHA class, 3.1 [0.36]; QRS duration, 144 [14] ms; LVEF, 21% [7.3%]; left ventricular end-diastolic diameter (LVEDD), 6.8 [0.56] mm) were evaluated. NYHA class, QRS duration, LVEF, and LVEDD were significantly improved at 3- and 6-month follow-ups both in patients aged 60 years (P < 0.001, except for aged
Conclusion: CRT response in these patients with HF did not appear to be gender or age related at 3- and 6-month follow-ups in this small observational study. Confirmation of these findings by larger studies is needed.