AI Article Synopsis
- A new injectable hydrogel has been developed that quickly forms a template for creating bone tissue by cross-linking specific compounds.
- The hydrogel incorporates bone morphogenetic protein-2 (BMP-2) to attract cells that help in bone growth, and tests showed significant bone formation in rats where BMP-2 was present.
- No inflammation or adverse reactions were observed, suggesting this hydrogel could be a useful ready-to-use option for bone tissue repair.
Article Abstract
Here we present a novel injectable hydrogel which forms a template for de novo formation of bone tissue. Hydrogel formation takes place in situ in less than 1 min by the cross-linking of multifunctional hyaluronic acid and polyvinyl alcohol derivatives. Endogenous cells are recruited in vivo by incorporating bone morphogenetic protein-2 (BMP-2), a powerful promoter for osteogenic differentiation. The hydrogel was evaluated in vitro by performing a cell viability test and a release study and in vivo by a rat ectopic model. Examination by X-ray, microcomputed tomography, and histology revealed a significant bone formation at the target site for gels containing BMP-2, and a complete degradation was observed for gels without BMP-2 four weeks after injection. There were no signs of inflammation or foreign body response in either group and we believe that this system has the potential as an off-the-shelf injectable to be used where bone tissue is needed.
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| http://dx.doi.org/10.1002/jbm.a.32289 | DOI Listing |
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