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Resveratrol is neuroprotective because it is not a direct activator of Sirt1-A hypothesis.
Brain Res Bull
March 2010
The plant polyphenol resveratrol (3,5,4'-trihydroxystilbene) has been touted to have multiple health benefits. A commonly cited mechanism of resveratrol action is via the activation of the longevity factor Sir2/Sirt1, whose deacetylase activity on several transcription factors has stress resistance and pro-survival effects. Resveratrol has been shown to be beneficial in various in vitro and in vivo models of central nervous system (CNS) neuron death and degeneration, presumably acting through Sirt1.
View Article and Find Full Text PDF[SIRT1--a potential target for the therapy of nonalcoholic steatohepatitis].
Zhonghua Gan Zang Bing Za Zhi
December 2008
Department of Gastroenterology, Renji Hospital, Medical College of Shanghai Jiaotong University, Shanghai 200001, China.
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