The involvement of Dr. Richard Mattingly, Editor of Obstetrics & Gynecology between 1972 and 1985, in the publication of an article on carcinoma in situ (CIS) of the cervix, facilitated exposure of an unethical study into the natural history of CIS of the cervix (now termed cervical intraepithelial neoplasia 3) by Dr. Herbert Green. The object of Dr. Green's study was to verify his premise that CIS was not a precursor of invasive cancer, and he published his "atypical viewpoint" that CIS was a benign disorder in international medical journals and the lay press. Alarmed by the number of women developing cancer and frustrated by the failure of the hospital authorities to deal with the problem, Dr. Bill McIndoe began presenting his interpretation of Dr. Green's study at international scientific meetings. Dr. Mattingly was aware of both Dr. Green's previous publications and the difficulties facing Dr. McIndoe, and he encouraged Dr. McIndoe to publish his data in Obstetrics & Gynecology. The correspondence between Dr. Mattingly, a senior U.S. academic and journal editor wishing to publish important scientific data, and Dr. McIndoe, an unknown antipodean clinician intent on revealing an unethical experiment, provides important lessons for all who practice medicine, in particular those in positions of responsibility.
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http://dx.doi.org/10.1097/AOG.0b013e3181917b27 | DOI Listing |
BMC Womens Health
January 2025
University of British Columbia Faculty of Medicine, Vancouver, BC, Canada.
Background: Although abortion was completely decriminalized in Canada 36 years ago, barriers to pregnancy prevention and termination persist across the country, such as travel and information gaps. Research demonstrates incarcerated people face barriers to family planning care, yet there is no systematic data collection of sexual and reproductive health experiences and outcomes among incarcerated people in Canada. The aim of this study was to explore family planning care experiences among women and gender diverse people who have experienced incarceration in Canada.
View Article and Find Full Text PDFGut Microbes
December 2025
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Assessing causality is undoubtedly one of the key questions in microbiome studies for the upcoming years. Since randomized trials in human subjects are often unethical or difficult to pursue, analytical methods to derive causal effects from observational data deserve attention. As simple covariate adjustment is not likely to account for all potential confounders, the idea of instrumental variable (IV) analysis is worth exploiting.
View Article and Find Full Text PDFBMC Med Ethics
January 2025
Bioethics Unit, Institute of Public, Health University of Nigeria Enugu Campus, Enugu, Nigeria.
Background: Stakeholders in medical research have roles in ensuring that research participants are protected. Medical journals play gatekeeping roles in the responsible conduct of research. They help guard against the publication of findings of unethical research, such as those with compromised participant welfare.
View Article and Find Full Text PDFJ Community Genet
January 2025
Department of Organization and Management in Health Care, Poznan University of Medical Sciences, Poznań, Poland.
Background: Despite the rise of research biobanks in the Middle East, they continue to struggle with the limited number of donors. Although qualified healthcare professionals may address it, the awareness of biobanks among future physicians is low. This paper assesses the attitudes towards research biobanks among Iranian medical students.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!