Background: Treatment of full-thickness talar cartilage defects that have failed previous surgery is problematic without a definitive solution.
Purpose: To report the first US prospective study of autologous chondrocyte implantation of the talus.
Study Design: Case series; Level of evidence, 4.
Methods: Eleven patients (6 women and 5 men; mean age, 33 years) underwent autologous chondrocyte implantation of the talus after previous failed surgical management. There were 9 medial and 2 lateral lesions, with a mean size of 21 x 13 mm (273 mm2). Five patients underwent autologous chondrocyte implantation of the talus alone; 6 had it with a "sandwich procedure." Ten patients underwent a second-look arthroscopy with screw removal.
Results: Mean follow-up was 38 months. Preoperatively, 10 patients rated their ankles as poor and 1 as fair, using the simplified symptomatology evaluation. At latest follow-up, 3 patients were classified as excellent, 6 as good, and 2 as fair. Tegner activity level improved from 1.3 +/- 1.0 (mean +/- SE) preoperatively to 4.0 +/- 1.6 (P < .002) postoperatively. The Finsen score (modified Weber score) showed significant improvement in the total score (P < .001). There was also overall agreement between the Finsen score and the American Orthopaedic Foot and Ankle Society ankle hindfoot score, with significant improvement from 47.4 +/- 17.4 preoperatively to 84.3 +/- 8.1 postoperatively (P < .001). At repeat arthroscopy, complete coverage of the defect was seen in all patients.
Conclusion: Autologous chondrocyte implantation of the talus yields significant functional improvement; however, further investigation is necessary to determine the long-term structural and biomechanical properties of the repair tissue.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/0363546508325670 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Emerging Strategies in Cartilage Repair and Joint Preservation.
Medicina (Kaunas)
December 2024
Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.
Cartilage repair remains a critical challenge in orthopaedic medicine due to the tissue's limited self-healing ability, contributing to degenerative joint conditions such as osteoarthritis (OA). In response, regenerative medicine has developed advanced therapeutic strategies, including cell-based therapies, gene editing, and bioengineered scaffolds, to promote cartilage regeneration and restore joint function. This narrative review aims to explore the latest developments in cartilage repair techniques, focusing on mesenchymal stem cell (MSC) therapy, gene-based interventions, and biomaterial innovations.
View Article and Find Full Text PDFHigh paracrine activity of hADSCs cartilage microtissues inhibits extracellular matrix degradation and promotes cartilage regeneration.
Mater Today Bio
February 2025
Institute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 51 Fucheng Road, Beijing, 100048, PR China.
Due to its unique structure, articular cartilage has limited self-repair capacity. Microtissues are tiny tissue clusters that can mimic the function of target organs or tissues. Using cells alone for microtissue construction often results in the formation of necrotic cores.
View Article and Find Full Text PDFCombination Treatment with Thread-Embedding Acupuncture and Electroacupuncture for Knee Osteoarthritis Patients with Postoperative Pain: A Randomized Controlled Feasibility Study.
J Pain Res
January 2025
Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea.
Purpose: This study aimed to evaluate the effectiveness and safety of combination treatment with thread-embedding acupuncture (TEA) and electroacupuncture (EA) in patients with persistent knee pain after arthroscopic surgery, autologous chondrocyte implantation, or autologous osteochondral transplantation.
Patients And Methods: Twelve patients with knee osteoarthritis (KOA) who experienced postoperative pain were randomized to either the treatment group (TG) or control group (CG) in a 1:1 ratio. The TG received TEA once a week for four sessions and EA twice a week for eight sessions while continuing usual care, defined as standard conventional treatments.
Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a huge burden on the health care system worldwide. Although traditional therapy and targeted cartilage cell therapy have made significant progress in the treatment of OA and cartilage regeneration, there are still many problems. Mesenchymal stem cells from various tissues are the most studied cell type and have been used in preclinical and clinical studies of OA, because they are more widely available, have a greater capacity for in expansion, and have anti-inflammatory and immunomodulatory properties compared to autologous chondrocytes.
View Article and Find Full Text PDFAdvancement of 3D biofabrication in repairing and regeneration of cartilage defects.
Biofabrication
January 2025
Department of Orthopaedics, Tangdu Hospital Fourth Military Medical University, 569 Xinsi Road, Baqiao District, Xi 'an City, Xi'an, Shaanxi, 710038, CHINA.
Three-dimensional (3D) bioprinting, an additive manufacturing technology, fabricates biomimetic tissues that possess natural structure and function. It involves precise deposition of bioinks, including cells, and bioactive factors, on basis of computer-aided 3D models. Articular cartilage injurie, a common orthopedic issue.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!