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Molecular profiling of bladder cancer xenografts defines relevant molecular subtypes and provides a resource for biomarker discovery.
Transl Oncol
January 2025
Johns Hopkins Greenberg Bladder Cancer Institute, Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA. Electronic address:
Bladder cancer (BLCA) genomic profiling has identified molecular subtypes with distinct clinical characteristics and variable sensitivities to frontline therapy. BLCAs can be categorized into luminal or basal subtypes based on their gene expression. We comprehensively characterized nine human BLCA cell lines (UC3, UC6, UC9, UC13, UC14, T24, SCaBER, RT4V6 and RT112) into molecular subtypes using orthotopic xenograft models.
View Article and Find Full Text PDFSpeech Kinematics and Perioral Muscle Activity Are Influenced by Stroop Effects.
J Speech Lang Hear Res
January 2025
Department of Communication Sciences and Disorders, Bowling Green State University, OH.
Purpose: The current project aimed to examine the effects of two experimental cognitive-linguistic paradigms, the Stroop task and a primed Stroop task, on speech kinematics and perioral muscle activation.
Method: Acoustic, kinematic, and surface electromyographic data were collected from the verbal responses of 30 young adult healthy control participants in choice response, classic Stroop, and primed Stroop tasks. The classic and primed Stroop tasks included congruent and incongruent trials.
Person-Specific Analyses of Smartphone Use and Mental Health: An Intensive Longitudinal Study Over One Year.
JMIR Form Res
December 2024
Department of Communication, Stanford University, Stanford, US.
Background: Contrary to popular concerns about the harmful effects of media use on mental health, research on this relationship is ambiguous, stalling advances in theory, interventions, and policy. Scientific explorations of the relationship between media and mental health have mostly found null or small associations, with the results often blamed on the use of cross-sectional study designs or imprecise measures of media use and mental health.
Objective: This exploratory empirical demonstration aimed to answer whether mental health effects are associated with media use experiences by (1) redirecting research investments to granular and intensive longitudinal recordings of digital experiences to build models of media use and mental health for single individuals over the course of one entire year, (2) using new metrics of fragmented media use to propose explanations of mental health effects that will advance person-specific theorizing in media psychology, and (3) identifying combinations of media behaviors and mental health symptoms that may be more useful for studying media effects than single measures of dosage and affect or assessments of clinical symptoms related to specific disorders.
Prevention of liver cancer in the era of next-generation antivirals and obesity epidemic.
Hepatology
January 2025
Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Preventive interventions are expected to substantially improve the prognosis of patients with primary liver cancer, predominantly hepatocellular carcinoma (HCC) and cholangiocarcinoma. HCC prevention is challenging in the face of the evolving etiological landscape, particularly the sharp increase in obesity-associated metabolic disorders, including metabolic dysfunction-associated steatotic liver disease (MASLD). Next-generation anti-HCV and HBV drugs have substantially reduced, but not eliminated, the risk of HCC and have given way to new challenges in identifying at-risk patients.
View Article and Find Full Text PDFManuscript Clarification for Edwards CM, da Silva DF, Puranda JL, Souza SCS, Semeniuk K, Adamo KB. Associations Between Rank, Sex, and Parity With Musculoskeletal Injuries Sustained During Annual Military Physical Fitness Test. J Strength Cond Res. 2024 Feb 1;38(2):367-373.
J Strength Cond Res
December 2024
Human Performance Research and Development, Directorate of Programs, Personnel Support Programs, Canadian Forces Morale and Welfare Services, Government of Canada, Ottawa, Ontario, Canada.
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