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Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression.
Carcinogenesis
January 2025
Instituto de Investigaciones en Ciencias de la Salud, INICSA (CONICET - FCM UNC), 5016 Córdoba, Argentina.
Pancreatic cancer is a devastating malignancy in great need of new and more effective treatment approaches. In recent years, studies have indicated that nutritional interventions, particularly nutraceuticals, may provide novel avenues to modulate cancer progression. Here, our study characterizes the impact of ω-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as a nutraceutical intervention in pancreatic cancer using a genetically engineered mouse model driven by KrasG12D and Trp53R172H.
View Article and Find Full Text PDFIntegrated biological-chemical system for phenol removal from petrochemicals wastewater.
Environ Sci Pollut Res Int
December 2024
Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, 163 Horria Ave. El-Shatby, P.O. Box 832, Alexandria, Egypt.
Phenol is a highly concerning pollutant in petrochemical industrial wastewater. It is extremely poisonous, carcinogenic, and persistent, therefore, it bioaccumulates in the food chain reaching humans, where it causes acute irritation to the skin, eyes, and respiratory tract, as well as chronic effects on the liver, kidneys, and nervous system. It spills or leaks easily into surface water or groundwater sources, leading to the creation of other harmful substituted compounds.
View Article and Find Full Text PDFPlastic additives affect estrogenic pathways and lipid metabolism in precision - cut - liver slices in Atlantic cod (Gadus morhua).
Sci Total Environ
December 2024
Department of Paraclinical Sciences, Norwegian University of Life Sciences, Oslo, Norway.
The overall aim of the present study was to determine if exposure to three high volume plastic additives, including diethylhexyl phthalate (DEHP), bisphenol A (BPA) and benzotriazoles (BT), have the potential to promote adverse effects in Atlantic cod (G. morhua). Ex vivo precision cut - liver slices (PCLS) from six male juvenile Atlantic cod were exposed to four concentrations of mono-(2-ethylhexyl)-phthalate (MEHP, the main metabolite of DEHP), BPA and BT both singly and in mixtures ranging from 0.
View Article and Find Full Text PDFHistopathological fingerprints and biochemical changes as multi-stress biomarkers in fish confronting concurrent pollution and parasitization.
iScience
December 2024
Enviromicrobiology, Ecotoxicology and Ecotechnology Research Laboratory (3E-MicroToxTech Lab), Department of Ecological Studies, University of Kalyani, Nadia, Kalyani, West Bengal 741 235, India.
The current investigation examined histopathological and serum biochemical profiles to assess the interactive effects of river Saraswati's impaired physicochemical regime and parasite infection by ectoparasites ( sp., sp.) and endoparasites ( sp.
View Article and Find Full Text PDFDetermination of vitamin D content in cod liver oil using column-switching technique.
Zhejiang Da Xue Xue Bao Yi Xue Ban
November 2024
Zhejiang Institute for Food and Drug Control, Hangzhou 310052, China.
Objectives: To develop a two-dimensional liquid chromatography method to determine the content of vitamin D in cod liver oil preparations.
Methods: The samples were prepared by saponification and extraction, and the content of vitamin D was determined by two-dimensional liquid chromatography with dual-pump-single-valve switching dual detectors. The chromatographic column, capture device, and detection wavelength were optimized; the linearity, system suitability, recovery rate, repeatability and sample stability of the method were investigated, and further validated in actual sample determination.
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