Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala.

Planta Med

Intituto de Química, Universidade Federal da Bahia, Campus de Ondina, Salvador (BA), Brazil.

Published: March 2009

Chemical investigation of the leaves of Waltheria brachypetala Turks (Sterculiaceae) resulted in the isolation of quinolinone alkaloids, waltherione-A, waltherione-B (N-methylwaltherione-A), 8-methoxyflindersine, and the cyclic peptide alkaloid waltherine. The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated. Waltherione-A, waltherione-B and waltherine showed significant activity.

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http://dx.doi.org/10.1055/s-0028-1112215DOI Listing

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