AI Article Synopsis
- - The study focuses on improving imidazo[1,2-a]pyridine inhibitors to enhance their effectiveness and selectivity against the IGF-1 receptor (IGF-1R).
- - It also addresses the optimization of these compounds for better oral absorption when tested in mice.
- - Additionally, the research highlights the detailed selectivity, lab activity, and pharmacokinetic (PK) profiles of the most optimized compound.
Article Abstract
The optimization of imidazo[1,2-a]pyridine inhibitors as potent and selective inhibitors of IGF-1R is presented. Further optimization of oral exposure in mice is also discussed. Detailed selectivity, in vitro activity, and in vivo PK profiles of an optimized compound is also highlighted.
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| http://dx.doi.org/10.1016/j.bmcl.2008.11.058 | DOI Listing |
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