Objective: To report a man with primary infertility and variant karyotype.
Design: Case report.
Setting: Private practice.
Patient(s): A 37-year-old man with 4 years of primary infertility due to oligoasthenozoospermia.
Intervention(s): None.
Main Outcome Measure(s): G- and C-banding. Polymerase chain reaction for SRY, DBY, RBMY, DAZ, AMELX, and AMELY.
Result(s): G-band analysis of the proband revealed a 46,XY,9ph,9qh+ karyotype. C-banding confirmed increase in the heterochromatin in one chromosome 9 and inversion in the other.
Conclusion(s): The morphologic difference between the homologous chromosomes 9 may have been responsible for an error in crossing-over, leading to aberrant spermatozoa and consequently to infertility.
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| http://dx.doi.org/10.1016/j.fertnstert.2008.10.057 | DOI Listing |
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