AI Article Synopsis
- The study aimed to investigate the link between melatonin secretion and blood pressure changes in hypertensive patients classified as 'dipping' or 'non-dipping' based on their nighttime blood pressure.
- Measurements were taken over 24 hours, comparing normal controls with both non-dipping and dipping hypertensive groups, revealing that non-dipping patients had less nighttime blood pressure reduction.
- Results indicated that while overall melatonin patterns were maintained, nighttime levels were significantly lower in the non-dipping group, suggesting a connection between reduced melatonin and disrupted circadian blood pressure rhythms.
Article Abstract
Objective: To observe the association between melatonin (MLT) secretion and blood pressure changes during 24 hours in hypertensive patients (HPT) with (dipping) or without (non-dipping) night time blood pressure reduction.
Methods: The 24-hour blood pressure and urine 6-SMT (6-sulfatoxymelatonin, metabolism product of MLT in urine) in the daytime and nighttime were measured in normal control subjects (n = 20), non-dipping HPT group (n = 32) and dipping HPT group (n = 36).
Results: As expected, blood pressure reduction during the night was significantly lower in non-dipping HPT group compared to control and dipping HPT groups. Nighttime 6-SMT was significantly higher than daytime 6-SMT in all groups and nighttime urine 6-SMT levels and ratio of nighttime/daytime urine 6-SMT levels were significantly lower in non-dipping HPT group compared to control and dipping HPT groups (all P < 0.01). Moreover, ratio of nighttime/daytime urine 6-SMT levels are positively correlated blood pressure reduction during nighttime (P < 0.05) in all groups.
Conclusions: Circadian rhythm of MLT secretion is maintained but nighttime MLT secretion was significantly reduced and related to disorders of circadian rhythm of blood pressure in non-dipping HPT group.
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