Purpose: We examined the construct validity of a porcine-intestine model for ultimately performing a laparoscopic urethrovesical anastomosis.
Materials And Methods: Pig intestine was used to create a model for laparoscopic urethrovesical anastomosis (L-UVA) performed laparoscopically in the LapTrainer. Twelve subjects (residents and medical students) with different levels of experience in laparoscopy were divided into three groups depending on their previous level of training with the laparoscope and with robot-assisted laparoscopic prostatectomy (RALP). Each subject performed a running laparoscopic anastomosis of pig intestine in the box trainer. Performance time and volume of leak from the anastomosis were recorded.
Results: Those in the most experienced group completed the anastomosis in an average of 34.30 min. Those in the less experienced group averaged 67.13 min, and those in the group with no experience averaged 114.72 min. The difference between the groups was significant with one-way analysis of variance (ANOVA) (P < 0.0001). Those in the most experienced group averaged 2.64 mL of leakage from the anastomosis; the less experienced subjects averaged 9.98 mL, and those in the group with no experience averaged 26.38 mL. The difference between the groups was significant with one-way ANOVA (P = 0.0005).
Conclusion: Tests of performance time and postoperative leakage accurately reflected the subjects' degree of experience, indicating that this model for L-UVA provides an experience closely resembling the person's past experience and that the porcine intestine provides a valid model for simulating the procedure. Measuring volume of leakage from the anastomosis provides an objective measure of the quality of the anastomosis.
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http://dx.doi.org/10.1089/end.2008.0058 | DOI Listing |
Sci Rep
January 2025
Department of Sports Medical Science, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Postoperative adhesion around nerves sometimes results in sensory and motor dysfunctions. To prevent these disorders, we have developed an electrospun nanofiber sheet incorporating methylcobalamin (MeCbl), an active form of vitamin B12 with anti-inflammatory and neuroregenerative effects. This study aimed to investigate the neuroprotective effects of MeCbl sheets against postoperative adhesion and to compare the effects of MeCbl sheets with those of porcine small intestinal submucosa (SIS) sheets using a rat sciatic nerve adhesion model.
View Article and Find Full Text PDFVirulence
December 2025
College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China.
Porcine deltacoronavirus (PDCoV) is increasingly prevalent in newborn piglets with diarrhea. With the development of research on the virus and the feasibility of PDCoV cross-species transmission, the biosafety and the development of pig industry have been greatly affected. In this study, a PDCoV strain CH/LNFX/2022 was isolated from diarrheal newborn piglets at a farm in China.
View Article and Find Full Text PDFJ Sci Food Agric
January 2025
Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Background: Piglets with different weaning body weights exhibit varying growth performance. This study explores the relationship between their plasma metabolites and gut microbiota to reveal differences in metabolic regulation and microbial composition.
Results: Plasma and colon content samples from piglets of different weaning weights were collected.
Physiol Rep
January 2025
Center for Translational Research in Aging and Longevity, Department of Health and Kinesiology, Texas A&M University, College Station, Texas, USA.
Sepsis leads to an acute breakdown of muscle to support increased caloric and amino acid requirements. Little is known about the role of adipose and muscle tissue breakdown and intestinal metabolism in glucose substrate supply during the acute phase of sepsis. In a translational porcine model of sepsis, we explored the across organ net fluxes of gluconeogenic substrates.
View Article and Find Full Text PDFVet Q
December 2025
Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
This study aimed to investigate the effects of dietary isatidis root polysaccharide (IRP) on diarrhea, immunity, and intestinal health in weanling piglets. Forty healthy piglets were randomly assigned to five groups receiving varying dosages of IRP. The findings indicated that different concentrations of IRP significantly reduced diarrhea scores ( < 0.
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